Factor V Leiden mutation and patent foramen ovale in ischemic stroke.

Abstract

We report a 47-years-old male with ischemic stroke, whose arteriographic and echocardiographic investigations did not reveal any steno-occlusive arterial disease or embolic source from the left cardiac chambers. A transesophageal echocardiogram showed a patent foramen ovale (PFO), whilst laboratory screening for coagulation abnormalities showed heterozygosity for factor V Leiden mutation. The significance of the association of PFO with factor V Leiden mutation is discussed as a possible cause of ischemic stroke through paradoxical embolism from a venous source. The high prevalence of these two conditions in the general population is emphasized and the indication for anticoagulant therapy is discussed.

• Authors: G Bezzi, W Bolzani, V Compagnoni, R Galimi, M G Palmieri, C Bianchi
• Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (Neurol Sci) Vol. 23 Issue 5 Pg. 229-31 (Dec 2002) ISSN: 1590-1874 [Print] Italy
• PMID: 12522679 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticoagulants
• factor V Leiden
• Factor V

Topics

• Activated Protein C Resistance
• Anticoagulants (therapeutic use)
• Brain Ischemia (genetics, physiopathology, therapy)
• Echocardiography, Transesophageal
• Embolism, Paradoxical (complications)
• Factor V (genetics)
• Frontal Lobe (diagnostic imaging)
• Heart Septal Defects, Atrial (physiopathology)
• Heterozygote
• Humans
• Male
• Middle Aged
• Point Mutation
• Prevalence
• Radiography
• Risk Factors
• Thrombophilia
• Tomography Scanners, X-Ray Computed