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Drug-induced hepatitis with hepatic granuloma due to saridon.

Abstract
A 38-year-old Japanese woman with no past history of liver disease developed liver dysfunction associated with fever, anorexia, and general malaise following the prolonged administration of saridon. A liver biopsy demonstrated multiple noncaseating epithelioid granulomas within hepatic lobules, with an inflammatory cell infiltrate of the lobular parenchyma and portal tracts. Viral markers and autoantibodies were negative. Lymphocyte stimulation tests for saridon and for isopropylantipyrine, one of the constituents of saridon, were positive, and therefore a diagnosis of drug-induced hepatitis due to administration of saridon was made. Her symptoms resolved and liver function test results returned to normal following discontinuation of the drug. The possibility of drug-induced hepatitis must be considered when liver dysfunction or systemic symptomatology develops during saridon therapy.
AuthorsMasanori Abe, Teru Kumagi, Seiji Nakanishi, Takashi Yamagami, Kojiro Michitaka, Kayo Abe, Izumi Okura, Haruhiko Yamashita, Norio Horiike, Morikazu Onji
JournalJournal of gastroenterology (J Gastroenterol) Vol. 37 Issue 12 Pg. 1068-72 ( 2002) ISSN: 0944-1174 [Print] Japan
PMID12522541 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Drug Combinations
  • Pyridones
  • Caffeine
  • Saridon
  • Phenacetin
  • Antipyrine
Topics
  • Adult
  • Antipyrine (adverse effects, analogs & derivatives, therapeutic use)
  • Biopsy, Needle
  • Caffeine (adverse effects, therapeutic use)
  • Chemical and Drug Induced Liver Injury (complications, etiology, pathology)
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Combinations
  • Female
  • Follow-Up Studies
  • Granuloma (chemically induced, complications, pathology)
  • Headache (diagnosis, drug therapy)
  • Humans
  • Immunohistochemistry
  • Liver Function Tests
  • Phenacetin (adverse effects, therapeutic use)
  • Pyridones (adverse effects, therapeutic use)
  • Risk Assessment
  • Severity of Illness Index

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