HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Steroid-induced polycystic kidneys in the newborn rat.

Abstract
The ability of prednisolone, prednisolone tertiary butyl acetate, and tertiary butyl acetate to induce cysts in the kidneys of 8-day-old rats has been examined following single intramuscular injection of the chemicals into newborn rats. The results indicate that only prednisolone tertiary butyl acetate-treated rats developed cysts to any marked extent. The daily injection of potassium chloride (from Day 2 to Day 7) into the prednisolone tertiary butyl acetate-treated rats prevented the formation of cysts. Similar injection of potassium bicarbonate failed to provide protection. Serum and urine electrolyte (potassium, sodium, and chloride) concentrations were also studied on the day of necropsy. The steroid-treated rats did not develop the hypokalemia observed by previous workers. Changes in electrolyte concentrations were noted in a number of instances, but these could not be causally related to cyst formation.
AuthorsJ F Crocker, A G Stewart, J M Sparling, M E Bruneau
JournalThe American journal of pathology (Am J Pathol) Vol. 82 Issue 2 Pg. 373-80 (Feb 1976) ISSN: 0002-9440 [Print] United States
PMID1251891 (Publication Type: Journal Article)
Chemical References
  • Bicarbonates
  • Electrolytes
  • Pharmaceutical Vehicles
  • prednisolone tebutate
  • Potassium Chloride
  • Prednisolone
  • Potassium
Topics
  • Animals
  • Animals, Newborn
  • Bicarbonates (therapeutic use)
  • Disease Models, Animal
  • Electrolytes (metabolism)
  • Female
  • Kidney Diseases, Cystic (chemically induced, pathology, prevention & control)
  • Pharmaceutical Vehicles
  • Potassium (therapeutic use)
  • Potassium Chloride (therapeutic use)
  • Prednisolone (analogs & derivatives)
  • Pregnancy
  • Rats

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: