Abstract | BACKGROUND: METHODS: RESULTS: Atypical prostatic hyperplasia characterized by piling up and/or papillary infolding of epithelial cells with concomitant stromal smooth muscle hyperplasia was seen in adult mice given subcutaneous injection of phenylephrine daily for 26 days. Phenylephrine induced hyperplasia was more severe proximally and was associated with significantly reduced rates of apoptosis (but no change in cell proliferation) in both stromal and epithelial compartments. Only the alpha(1A)-adrenoceptor selective subtype antagonist RS100329 abrogated the phenylephrine-induced hyperplasia. Using selective antibodies, the alpha(1A-1)-adrenoceptor subtype was predominantly localized to the stromal compartments of the mouse and rat ventral prostates. The effects of phenylephrine were mediated independent of testicular androgens. CONCLUSIONS:
Prostatic hyperplasia in mice occurs as a consequence of subchronic administration of the sympathomimetic phenylephrine. Response to phenylephrine is mediated by the alpha(1A)-adrenoceptor, which predominates in the stroma of the rodent ventral prostate. Conceivably, therefore, phenylephrine could directly modulate prostate stromal growth, and indirectly modulate epithelial growth in a paracrine fashion. We cannot, however, rule out the contribution of other indirect effects such as hypoxia/reperfusion or effects on intermediary metabolism.
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Authors | Dorene Marinese, Rupa Patel, Paul D Walden |
Journal | The Prostate
(Prostate)
Vol. 54
Issue 3
Pg. 230-7
(Feb 15 2003)
ISSN: 0270-4137 [Print] United States |
PMID | 12518328
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Copyright | Copyright 2002 Wiley-Liss, Inc. |
Chemical References |
- Adrenergic alpha-1 Receptor Antagonists
- Adrenergic alpha-2 Receptor Antagonists
- Adrenergic alpha-Agonists
- Adrenergic alpha-Antagonists
- Sympathomimetics
- Phenylephrine
- Testosterone
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Topics |
- Adrenergic alpha-1 Receptor Antagonists
- Adrenergic alpha-2 Receptor Antagonists
- Adrenergic alpha-Agonists
(pharmacology)
- Adrenergic alpha-Antagonists
(pharmacology)
- Animals
- Apoptosis
(drug effects)
- Cell Division
(drug effects)
- Male
- Mice
- Mice, Inbred C57BL
- Phenylephrine
(pharmacology)
- Prostatic Hyperplasia
(chemically induced, pathology)
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Stromal Cells
(pathology)
- Sympathomimetics
(pharmacology)
- Testis
(metabolism)
- Testosterone
(biosynthesis)
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