Abstract | OBJECTIVE: DESIGN: Double-blind, randomized, placebo-controlled clinical trial. SETTING: Pediatric emergency department. PATIENTS: From a convenience sample of wheezing children aged 2 to 24 months, 85 patients were enrolled in the nebulizer group and 83 in the spacer group. INTERVENTIONS: MAIN OUTCOME MEASURES: The primary outcome was admission rate. Pulmonary Index score and oxygen saturation were measured initially and 10 minutes after each treatment. RESULTS: The nebulizer group had a significantly higher mean (SD) initial Pulmonary Index score compared with the spacer group (7.6 [2.5] vs 6.6 [2.0]; P =.002). With the initial Pulmonary Index score controlled, children in the spacer group were admitted less (5% vs 20%; P =.05). Analyses also revealed an interaction between group and initial Pulmonary Index score; lower admission rates in the spacer group were found primarily in children having a more severe asthma exacerbation. CONCLUSION:
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Authors | Annette Delgado, Katherine J Chou, Ellen Johnson Silver, Ellen F Crain |
Journal | Archives of pediatrics & adolescent medicine
(Arch Pediatr Adolesc Med)
Vol. 157
Issue 1
Pg. 76-80
(Jan 2003)
ISSN: 1072-4710 [Print] United States |
PMID | 12517199
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Bronchodilator Agents
- Albuterol
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Topics |
- Albuterol
(administration & dosage)
- Bronchodilator Agents
(administration & dosage)
- Child, Preschool
- Double-Blind Method
- Emergency Service, Hospital
- Female
- Humans
- Infant
- Male
- Metered Dose Inhalers
- Nebulizers and Vaporizers
- New York City
- Respiration
(drug effects)
- Respiratory Sounds
(drug effects)
- Treatment Outcome
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