Abstract | PROBLEM: METHODS: In order to investigate the direct effect of IgG purified from women with SLE or APS on the growth and viability of embryos, we cultured 11.5-day old-rat embryos in their yolk sacs in the presence of IgG purified from SLE and APS patients. RESULTS:
IgG purified from SLE and recurrent pregnancy loss (RPL) patients affected directly the embryo and yolk sac reducing their growth. The purified IgG positive for anti- cardiolipin/ anti-DNA antibodies reduced yolk sac and embryonic growth more than sera negative for these antibodies. CONCLUSION:
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Authors | S T Matalon, Y Shoenfeld, M Blank, S Yacobi, Z Blumenfeld, A Ornoy |
Journal | American journal of reproductive immunology (New York, N.Y. : 1989)
(Am J Reprod Immunol)
Vol. 48
Issue 5
Pg. 296-304
(Nov 2002)
ISSN: 1046-7408 [Print] Denmark |
PMID | 12516651
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Congenital Abnormalities
(etiology, physiopathology)
- Embryo, Mammalian
(drug effects)
- Female
- Humans
- Immunoglobulin G
(administration & dosage, immunology)
- In Vitro Techniques
- Lupus Erythematosus, Systemic
(immunology)
- Pregnancy
- Pregnancy Outcome
(veterinary)
- Rats
- Yolk Sac
(drug effects, growth & development)
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