Rosiglitazone improves insulin resistance, lipid profile and promotes adiposity in a genetic model of metabolic syndrome X.

Abstract

RSG is a member of the TZD group of drugs widely used in treatment of type 2 diabetes. The underlying mechanism of TZD action in insulin-sensitive tissues is not fully understood. In this study we show that 14-day RSG administration in a new rodent model of metabolic syndrome X, polydactylous rat strain (PD/Cub), substantially improves its lipid profile (serum TGs 4.20 +/- 0.23 vs 2.34 +/- 0.14 mmol/l, P < 0.0001; FFA 0.46 +/- 0.05 vs 0.33 +/- 0.02 mmol/l, P = 0.017), diminishes the liver TG depots (15.76 +/- 0.60 vs 8.44 +/- 0.55 micromol/g, P < 0.0001), serum insulin concentrations (1.10 +/- 0.08 vs 0.63 +/- 0.02 nmol/l, P < 0.0001) and promotes visceral adiposity (adiposity index 1.28 +/- 0.03 vs 1.85 +/- 0.07, P < 0.0001). No changes were observed in serum or liver concentrations of cholesterol. Concomitantly, both basal and insulin-stimulated glycogen synthesis in red-fibre type muscle (m. soleus) was enhanced, as well as glucose uptake into adipose tissue. However, glucose oxidation in soleus (basal and insulin-stimulated) remained unchanged. In consent with previously published data we suggest the current pharmacogenetic study as a further proof of substantial influence of genetic background on the physiological outcome of TZD therapy.

• Authors: O Seda, L Kazdová, D Krenová, V Kren
• Journal: Folia biologica (Folia Biol (Praha)) Vol. 48 Issue 6 Pg. 237-41 ( 2002) ISSN: 0015-5500 [Print] Czech Republic
• PMID: 12512799 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hypoglycemic Agents
• Insulin
• Lipids
• Thiazoles
• Thiazolidinediones
• Rosiglitazone
• Glycogen
• Glucose

Topics

• Adipose Tissue (metabolism)
• Animals
• Disease Models, Animal
• Glucose (metabolism)
• Glucose Tolerance Test
• Glycogen (metabolism)
• Hypoglycemic Agents (pharmacology)
• Insulin (metabolism)
• Insulin Resistance
• Lipids (blood)
• Male
• Metabolic Syndrome (metabolism)
• Rats
• Rats, Inbred Strains
• Rosiglitazone
• Thiazoles (pharmacology)
• Thiazolidinediones