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[A pharmacodynamic research on chromone glucosides of fangfeng].

AbstractOBJECTIVE:
To investigate the pharmacological activity of prim-O-glucosylcimifugin and 4'-O-beta-D-glucosyl-5-O-methylvisamminol con tained in Fangfeng.
METHODS:
Analgesic, antipyretic and antiinflammatory effects were assessed using the models of yeast-induced rat fever, acetic acidinduced peritoneal pain thermalpain, and dimethylbenzol-induced mouse ear edema.
RESULTS:
Prim-O-glucosylcimifugin and 4'-O-beta-D-glucosyl-5-O-methylvisamminol could reduce the body temperature of rats in a model of yeast-induced fever. Both components could decrease the spasm action induced by peritoneal injection of acetic acid, increase the pain-threshold in a thermal-pain model, relieve the mouse ear edema caused by dimethybenzol and significantly inhibit ADP-induced platelet aggregation.
CONCLUSION:
Prim-O-glucosylcimifugin and 4'-O-beta-D-glucosyl-5-O-methylvisamminol have significant analgesic, antipyretic, anti-inflammatory and anti-platelet aggregation actions.
AuthorsB Y Xue, W Li, L Li, Y Q Xiao
JournalZhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 25 Issue 5 Pg. 297-9 (May 2000) ISSN: 1001-5302 [Print] China
PMID12512455 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents, Non-Steroidal
  • Drugs, Chinese Herbal
Topics
  • Analgesics, Non-Narcotic (pharmacology)
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Apiaceae (chemistry)
  • Drugs, Chinese Herbal (isolation & purification, pharmacology)
  • Female
  • Male
  • Mice
  • Plant Roots (chemistry)
  • Plants, Medicinal (chemistry)
  • Platelet Aggregation (drug effects)
  • Rats

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