[Effectiveness of virazol, realdiron and interferon inductors in experimental Omsk hemorrhagic fever].

Abstract

Efficacy of drug therapy of Omsk hemorrhagic fever (OHF) was tested experimentally using cell culture and laboratory animals infected with the OHF virus strain Ondatra. Screening tests showed that high concentrations of Virazol or interferon inducers Larifan and Rifastin caused moderately pronounced suppression of virus reproduction in cell culture. Realdiron was found to be a high-efficacy preparation causing complete inhibition of virus reproduction in cell. Larifan demonstrated the highest antiviral efficacy against OHF virus in experiments with laboratory animals. This drug prevented the death of 65% infected mice and significantly decreased infection process severity in rabbits.

• Authors: S Ia Loginova, T N Efanova, A V Koval'chuk, V N Faldina, I A Androshchuk, M N Pistsov, S V Borisevich, N K Kopylova, Iu I Pashchenko, P A Khamitov, V A Maksimov, N T Vasil'ev
• Journal: Voprosy virusologii (Vopr Virusol) 2002 Nov-Dec Vol. 47 Issue 6 Pg. 27-30 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' virazola, real'dirona i induktorov interferona pri éksperimental'noĭ omskoĭ gemorragicheskoĭ likhoradke.
• PMID: 12508680 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antiviral Agents
• Interferon Inducers
• Interferon Type I
• Organic Chemicals
• Recombinant Proteins
• larifan
• Ribavirin

Topics

• Animals
• Antiviral Agents (therapeutic use)
• Cell Culture Techniques
• Disease Models, Animal
• Disease Progression
• Encephalitis Viruses, Tick-Borne
• Hemorrhagic Fever, Omsk (drug therapy, pathology)
• Interferon Inducers (therapeutic use)
• Interferon Type I (therapeutic use)
• Mice
• Organic Chemicals
• Rabbits
• Recombinant Proteins
• Ribavirin (therapeutic use)
• Virus Replication (drug effects)