Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and intramuscular administration to horses.

Abstract

The pharmacokinetic properties of norfloxacin-glycine acetate (NFLXGA) were determined in six horses following a single intravenous (i.v.) and intramuscular (i.m.) dose of 4 mgkg(-1) body weight. Following i.v. and i.m. administration, the plasma drug concentrations were best fitted by an open two-compartment model with a rapid distribution phase. After i.v. NFLXGA administration, the distribution (t(1/2alpha)) and elimination half-life (t(1/2beta)) were 0.42 (0.05) and 5.44 (1.36)h. The volume of distribution of NFLXGA at steady state (Vd(ss)) was 2.19 (0.53) Lkg(-1). After NFLXGA i.m. administration, the maximal absorption concentration (C(max)) was 0.44 (0.04) microgml(-1) at 0.86 (0.15)h (T(max)). The mean absorption (t(1/2ka)) and elimination half-life (t(1/2beta)) of NFLXGA were 0.27 (0.07) and 9.47 (2.24)h, respectively. The mean systemic bioavailability (F) following i.m. administration was 55 (12)%. The optimal dosage for each administration route was calculated from the pharmacokinetic data on the basis of the area under the inhibitory plasma concentration-time curve (AUIC) every 24h and was found to be 13.36 and 7.35 mgkg(-1) for i.m. and i.v. administration, respectively.

• Authors: S-C Park, H-I Yun
• Journal: Research in veterinary science (Res Vet Sci) Vol. 74 Issue 1 Pg. 79-83 (Feb 2003) ISSN: 0034-5288 [Print] England
• PMID: 12507569 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents
• Fluoroquinolones
• norfloxacin-glycine acetate
• Norfloxacin
• Glycine

Topics

• Absorption
• Animals
• Anti-Infective Agents (administration & dosage, blood, pharmacokinetics)
• Area Under Curve
• Biological Availability
• Cross-Over Studies
• Fluoroquinolones
• Glycine (administration & dosage, analogs & derivatives, blood, pharmacokinetics)
• Half-Life
• Horses (metabolism)
• Injections, Intramuscular
• Injections, Intravenous
• Male
• Norfloxacin (administration & dosage, analogs & derivatives, blood, pharmacokinetics)