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[Effect of purified staphylococcal toxoid preparation on the in vitro production of interferon by leukocytes from patients with atopic dermatitis].

Abstract
The impact of purified staphylococcal toxoid (PST) on the in vitro production of interferon (IFN) by blood leukocytes was evaluated. PST was found to produce a stimulating effect on the production of alpha-IFN in patients with atopic dermatitis (AD): in 88% of cases a two-fivefold increase in IFN production was observed in AD patients in comparison with healthy donors. In addition, the incubation of leukocytes obtained from atopic and nonatopic patients with PST was shown to stimulate the production of gamma-IFN by these leukocytes fivefold, on the average. These results give theoretical basis for use of PST (as an inducer of endogenic IFN) for AD patients treatment.
AuthorsM A Mokronosova, T P Ospel'nikova, T V Liaporova, E A Ruzova, S S Grigorian
JournalZhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) 2002 Nov-Dec Issue 6 Pg. 52-5 ISSN: 0372-9311 [Print] Russia (Federation)
Vernacular TitleVliianie preparata stafilokokkovogo ochishchennogo anatoksina na produktsiiu interferona leĭkotsitami in vitro u bol'nykh atopicheskim dermatitom.
PMID12506629 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Interferon-alpha
  • Staphylococcal Toxoid
  • Interferon-gamma
Topics
  • Cells, Cultured
  • Dermatitis, Atopic (blood, immunology)
  • Humans
  • In Vitro Techniques
  • Interferon-alpha (biosynthesis, drug effects)
  • Interferon-gamma (biosynthesis, drug effects)
  • Leukocytes, Mononuclear (immunology)
  • Male
  • Staphylococcal Toxoid (isolation & purification, pharmacology)

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