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omega-3 Fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot study.

AbstractOBJECTIVE:
The purpose of this study was to compare the efficacy of ethyl-eicosapentaenoic acid (E-EPA) and placebo in the treatment of female subjects with borderline personality disorder.
METHOD:
The authors conducted an 8-week, placebo-controlled, double-blind study of E-EPA in 30 female subjects meeting Revised Diagnostic Interview for Borderlines and DSM-IV criteria for borderline personality disorder.
RESULTS:
Twenty subjects were randomly assigned to 1 g of E-EPA; 10 subjects were given placebo. Ninety percent of those in both groups completed all 8 weeks of the trial. Analyses that used random-effects regression modeling and controlled for baseline severity showed E-EPA to be superior to placebo in diminishing aggression as well as the severity of depressive symptoms.
CONCLUSIONS:
The results of this study suggest that E-EPA may be a safe and effective form of monotherapy for women with moderately severe borderline personality disorder.
AuthorsMary C Zanarini, Frances R Frankenburg
JournalThe American journal of psychiatry (Am J Psychiatry) Vol. 160 Issue 1 Pg. 167-9 (Jan 2003) ISSN: 0002-953X [Print] United States
PMID12505817 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Fatty Acids, Omega-3
  • eicosapentaenoic acid ethyl ester
  • Eicosapentaenoic Acid
Topics
  • Adult
  • Aggression (drug effects, psychology)
  • Borderline Personality Disorder (diagnosis, drug therapy, psychology)
  • Depressive Disorder (diagnosis, drug therapy, psychology)
  • Double-Blind Method
  • Drug Therapy, Combination
  • Eicosapentaenoic Acid (administration & dosage, analogs & derivatives)
  • Fatty Acids, Omega-3 (administration & dosage)
  • Female
  • Follow-Up Studies
  • Humans
  • Pilot Projects
  • Psychiatric Status Rating Scales
  • Treatment Outcome

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