BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer?

Abstract

The mechanistic link between the BRCA2 protein, homologous recombination, and genomic instability has become clearer as a result of recent work describing the structures of different BRCA2 domains bound to Rad51 and to single-stranded DNA.

• Authors: Simon N Powell, Henning Willers, Fen Xia
• Journal: Molecular cell (Mol Cell) Vol. 10 Issue 6 Pg. 1262-3 (Dec 2002) ISSN: 1097-2765 [Print] United States
• PMID: 12504001 (Publication Type: Comment, Journal Article)

Chemical References

• BRCA2 Protein
• DNA-Binding Proteins
• RAD51 protein, human
• Rad51 Recombinase

Topics

• BRCA2 Protein (genetics)
• Breast Neoplasms (genetics, prevention & control)
• DNA-Binding Proteins (genetics)
• Female
• Gene Expression Regulation
• Genes, BRCA2
• Humans
• Models, Genetic
• Ovarian Neoplasms (genetics, prevention & control)
• Rad51 Recombinase
• Recombination, Genetic