Abstract | BACKGROUND: CASE REPORT: In the present case Recombinant Coagulation Factor VIIa ( rFVIIa) was used for preoperative reversal of Warfarin-related coagulopathy. The patient was a fifty two years old man, mechanic valve recipient with Warfarin-induced coagulopathy: International Normalization Ratio (INR) of 6.39, who suffered from acute subdural hematoma and needed urgent neurosurgical intervention. He received a single dose of rFVIIa 120 mg/kg and immediately underwent craniotomy and evacuation of the hematoma. Appropriate hemostasis was achieved during surgery and coagulation test taken two hours after rFVIIa injection revealed INR of 1.25. The INR remained normalized for additional 14 hours. To the best of our knowledge, this is the first report on the use of rFVIIa in the preoperative management of Warfarin-induced intracranial hemorrhage. RESULTS:
Recombinant Coagulation Factor VIIa provides rapid correction of coagulation to a level that allows safe neurosurgical intervention without significant delay. This agent is safe and effective; and should be considered for reversal of Warfarin-induced coagulopathy in cases of intracranial hemorrhage, especially when urgent surgical intervention is required.
|
Authors | Igor Veshchev, Hanoch Elran, Khalil Salame |
Journal | Medical science monitor : international medical journal of experimental and clinical research
(Med Sci Monit)
Vol. 8
Issue 12
Pg. CS98-100
(Dec 2002)
ISSN: 1234-1010 [Print] United States |
PMID | 12503044
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Recombinant Proteins
- Warfarin
- Factor VIIa
|
Topics |
- Craniotomy
- Factor VIIa
(administration & dosage)
- Heart Valve Prosthesis
- Hematoma, Subdural, Acute
(drug therapy, etiology, surgery)
- Hemostasis, Surgical
- Humans
- Male
- Middle Aged
- Preoperative Care
- Recombinant Proteins
(administration & dosage)
- Warfarin
(adverse effects)
|