Primary dysmenorrhea treatment with a desogestrel-containing low-dose oral contraceptive.

Abstract

This randomized, double-blind, placebo-controlled exploratory study examined the efficacy and safety of a low-dose oral contraceptive (Mircette), desogestrel/ethinyl estradiol [DSG/EE] and ethinyl estradiol [EE]) in relieving the symptoms of dysmenorrhea. Twenty-three clinics in the United States enrolled 77 women (age < or =32 years) with primary dysmenorrhea documented for at least four consecutive cycles. Forty participants received DSG/EE&EE and 37 received placebo for four consecutive 28-day cycles. The intensity of menstrual-related distress was measured with the Menstrual Distress Questionnaire (MDQ). Patient diaries were used to assess number of school/work days missed as well as the use of rescue medication. Participants receiving DSG/EE&EE recorded reduced menstrual pain severity, lower total MDQ scores, and significantly less menstrual cramping. No significant change in bloating, anxiety, loneliness, weight gain, or acne was reported. The DSG/EE&EE formulation shows promise for the treatment of primary dysmenorrhea and was well tolerated by the participants in this study.

• Authors: Susan L Hendrix, Nancy J Alexander
• Journal: Contraception (Contraception) Vol. 66 Issue 6 Pg. 393-9 (Dec 2002) ISSN: 0010-7824 [Print] United States
• PMID: 12499030 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2002 Elsevier Science Inc.

Chemical References

• Contraceptives, Oral, Synthetic
• Placebos
• Ethinyl Estradiol
• Desogestrel

Topics

• Adult
• Contraceptives, Oral, Synthetic (administration & dosage, adverse effects)
• Desogestrel (administration & dosage, adverse effects)
• Double-Blind Method
• Dysmenorrhea (drug therapy)
• Ethinyl Estradiol (administration & dosage)
• Female
• Headache (chemically induced)
• Humans
• Placebos
• Treatment Outcome
• United States