Gastric bilirubin monitoring to assess duodenogastric reflux.

Abstract

Duodenogastric reflux (DGR) was assessed with 24-hour gastric bilirubin monitoring in 345 patients (219 men; 49 +/- 13 years) with foregut symptoms and 41 healthy subjects (24 men, 28 +/- 5 years). Bilirubin exposure was measured as percent time above absorbance level 0.25 and excessive DGR was defined above the 95th percentile of normal values (>24.8%). DGR was highest following Billroth II gastric resection (60 +/- 24%, N = 15). Patients after cholecystectomy (28 +/- 25%, N = 25), patients with gastroesophageal reflux disease (24 +/- 24%, N = 199), and patients with nonulcer dyspepsia (23 +/- 21%, N = 61) had a significantly higher exposure to DGR than healthy subjects (7 +/- 8%, P < 0.0001). In conclusion, gastric bilirubin monitoring is useful for the assessment of DGR specifically in symptomatic patients following gastric resection. Increased amounts of DGR may further be of clinical importance in patients with reflux disease or nonulcer dyspepsia and following cholecystectomy.

• Authors: Martin Fein, Stephan M Freys, Marco Sailer, Jörn Maroske, Harald Tigges, Karl-Hermann Fuchs
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 47 Issue 12 Pg. 2769-74 (Dec 2002) ISSN: 0163-2116 [Print] United States
• PMID: 12498300 (Publication Type: Journal Article)

Chemical References

• Bilirubin

Topics

• Adult
• Bilirubin (analysis)
• Duodenogastric Reflux (diagnosis, metabolism)
• Dyspepsia (metabolism)
• Female
• Gastric Mucosa (metabolism)
• Humans
• Male
• Middle Aged
• Monitoring, Physiologic