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Synthesis of N-hydroxythiourea.

Abstract
The synthesis of the title compound (1) was accomplished by the conversion of 2,4-dimethoxybenzylamine (2) into an isothiocyanate (3) using thiocarbonyl diimidazole. Treatment of 3 with hydroxylamine and removal of the DMB group with trifluoroacetic acid gave 1. N-Hydroxythiourea (1) showed no activity in the L1210 mouse tumor.
AuthorsM Sato, C H Stammer
JournalJournal of medicinal chemistry (J Med Chem) Vol. 19 Issue 2 Pg. 336-7 (Feb 1976) ISSN: 0022-2623 [Print] United States
PMID1249817 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • N-hydroxythiourea
  • Thiourea
Topics
  • Animals
  • Leukemia L1210 (drug therapy)
  • Mice
  • Thiourea (analogs & derivatives, chemical synthesis, therapeutic use)

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