Abstract | AIM: To study bronchial reactivity and sensitivity with consideration of histamine, serotonin and catecholamines concentration in bronchial mucosa in patients with acute bronchitis (AB) as possible criteria of its becoming chronic. MATERIAL AND METHODS: Before the treatment 116 patients with verified AB were examined using inhalation provocative tests (IPT) with histamine, serotonin and obsidian in increasing doses. Also, external respiration function was studied. IPT were repeated after the course of treatment. RESULTS: 87 of 116 AB patients exhibited high bronchial sensitivity and reactivity to inhalations of histamine, serotonin, obsidian. In parallel, there was a rise in the levels of histamine and serotonin and a fall in the level of catecholamines in bronchial mucosa (alveolar macrophages, lymphocytes, neutrophils, mast and APUD-cells). Changes in monoamines concentration in bronchial mucosa were relevant to activity of bronchial inflammation and the presence of obstructive syndrome. CONCLUSION:
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Authors | E G Artem'eva, I A Latfullin |
Journal | Terapevticheskii arkhiv
(Ter Arkh)
Vol. 74
Issue 11
Pg. 77-9
( 2002)
ISSN: 0040-3660 [Print] Russia (Federation) |
Vernacular Title | Reaktivnost' bronkhov i bioaminy slizistoĭ obolochki kak kriteriĭ khronizatsii ostrogo bronkhita. |
PMID | 12498137
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Acute Disease
- Adolescent
- Adult
- Bronchi
(physiopathology)
- Bronchitis
(metabolism, physiopathology)
- Catecholamines
(metabolism)
- Chronic Disease
- Histamine
(administration & dosage)
- Humans
- Middle Aged
- Mucous Membrane
(metabolism)
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