Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys.

Abstract

To investigate the protective effects of ligustrazine on renal ischemia-reperfusion injury, the influence of ligustrazine injection on plasma superoxide dismutase (SOD), malondialdehyde (MDA), and endothelin-1 (ET-1), as well as changes of morphology of renal tubules, were studied in rat kidney models with ischemia-reperfusion injury. The results showed that in the group treated with ligustrazine, the plasma SOD level was significantly higher than that of the control group (P < 0.05), but levels of plasma MDA and ET-1 and the pathological grading of injured renal tubules were significantly lower than those in the control group (P < 0.05). These findings suggest that ligustrazine has protective effects against ischemia-reperfusion injury in rat kidneys.

• Authors: Lijiang Sun, Yujun Li, Jingsen Shi, Xiao Wang, Xiang Wang
• Journal: Microsurgery (Microsurgery) Vol. 22 Issue 8 Pg. 343-6 ( 2002) ISSN: 0738-1085 [Print] United States
• PMID: 12497570 (Publication Type: Journal Article)
• Copyright: Copyright 2002 Wiley-Liss, Inc. MICROSURGERY 22:343-346 2002

Chemical References

• Endothelin-1
• Free Radical Scavengers
• Pyrazines
• Malondialdehyde
• Superoxide Dismutase
• tetramethylpyrazine

Topics

• Animals
• Disease Models, Animal
• Endothelin-1 (blood)
• Free Radical Scavengers (therapeutic use)
• Kidney (drug effects, pathology)
• Kidney Diseases (etiology, pathology, prevention & control)
• Malondialdehyde (blood)
• Pyrazines (therapeutic use)
• Random Allocation
• Rats
• Rats, Wistar
• Renal Artery (drug effects, pathology)
• Reperfusion Injury (complications, drug therapy, pathology)
• Superoxide Dismutase (blood)