Abstract | RATIONALE AND OBJECTIVES: MATERIALS AND METHODS: RESULTS: (1) Ioxaglate prolonged TTO when compared with saline (30.0 +/- 1.1 minute vs. 19.6 +/- 2.4 minutes, P< 0.001), whereas iohexol had no effect (21.3 +/- 1.3 minutes). Ioxaglate's effect was associated with a reduction in TW with ioxaglate versus saline (2.6 +/- 0.4 mg and 4.7 +/- 0.7 mg, respectively, P< 0.05) whereas TW remained unchanged in the iohexol group (4.2 +/- 0.4 mg). The nonionic dimer iodixanol induced a direct vasoconstrictor effect on the carotid artery and was consequently excluded from the study. (2) Neither iso-osmolar nor hyperosmolar solutions of meglumine had any effect on TTO whereas both sodium and meglumine salts of ioxaglic acid prolonged TTO, suggesting that the antithrombotic effect of ioxaglate is mediated by the ioxaglic acid moiety alone as neither meglumine, osmolality or sodium played a significant role. (3) A synergistic effect on TTO was found when ioxaglate was associated with clopidogrel whereas no such effect was observed with iohexol. CONCLUSIONS: These data show a greater in vivo antithrombotic potential for the ionic contrast medium ioxaglate than for the non-ionic contrast medium iohexol and, for the first time, a synergistic effect between a contrast medium and a platelet antiaggregant drug in vivo.
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Authors | Benoît Labarthe, Jean-Marc Idee, Roger Burnett, Claire Corot |
Journal | Investigative radiology
(Invest Radiol)
Vol. 38
Issue 1
Pg. 34-43
(Jan 2003)
ISSN: 0020-9996 [Print] United States |
PMID | 12496519
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Contrast Media
- Platelet Aggregation Inhibitors
- Iohexol
- Clopidogrel
- Ticlopidine
- Ioxaglic Acid
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Topics |
- Animals
- Carotid Artery Thrombosis
(drug therapy)
- Clopidogrel
- Contrast Media
(pharmacology, therapeutic use)
- Drug Synergism
- Iohexol
(pharmacology, therapeutic use)
- Ioxaglic Acid
(pharmacology, therapeutic use)
- Male
- Models, Animal
- Platelet Aggregation Inhibitors
(pharmacology)
- Rats
- Rats, Wistar
- Ticlopidine
(analogs & derivatives, pharmacology)
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