Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.

Abstract

The signaling pathway downstream of the mammalian interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) is evolutionally conserved with that mediated by the Drosophila Toll protein. Toll initiates its signal through the adapter molecule Tube and the serine-threonine kinase Pelle. Pelle is highly homologous to members of the IL-1R-associated kinase (IRAK) family in mammals. Recently, a novel Pelle-interacting protein called Pellino was identified in Drosophila. We now report a mammalian counterpart of Pellino, termed Pellino 1, which is required for NF kappa B activation and IL-8 gene expression in response to IL-1, probably through its signal-dependent interaction with IRAK4, IRAK, and the tumor necrosis factor receptor-associated factor 6 (TRAF6). The Pellino 1-IRAK-IRAK4-TRAF6 signaling complex is likely to be intermediate, located between the IL-1 receptor complex and the TAK1 complex in the IL-1 pathway.

• Authors: Zhengfan Jiang, H Jan Johnson, Huiqing Nie, Jinzhong Qin, Timothy A Bird, Xiaoxia Li
• Journal: The Journal of biological chemistry (J Biol Chem) Vol. 278 Issue 13 Pg. 10952-6 (Mar 28 2003) ISSN: 0021-9258 [Print] United States
• PMID: 12496252 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• DNA, Complementary
• Interleukin-1
• Interleukin-8
• NF-kappa B
• Nuclear Proteins
• Proteins
• Receptors, Tumor Necrosis Factor
• Recombinant Proteins
• TNF Receptor-Associated Factor 6
• PELI1 protein, human
• Ubiquitin-Protein Ligases
• Phosphotransferases (Alcohol Group Acceptor)
• IRAK4 protein, human
• Interleukin-1 Receptor-Associated Kinases

Topics

• Amino Acid Sequence
• DNA, Complementary
• Gene Expression Regulation (physiology)
• Humans
• Interleukin-1 (physiology)
• Interleukin-1 Receptor-Associated Kinases
• Interleukin-8 (genetics)
• Molecular Sequence Data
• NF-kappa B (metabolism)
• Nuclear Proteins (metabolism, physiology)
• Phosphotransferases (Alcohol Group Acceptor) (metabolism)
• Precipitin Tests
• Proteins (metabolism)
• Receptors, Tumor Necrosis Factor (metabolism)
• Recombinant Proteins (metabolism)
• Sequence Homology, Amino Acid
• Signal Transduction (physiology)
• TNF Receptor-Associated Factor 6
• Ubiquitin-Protein Ligases