Diayangambin exerts immunosuppressive and anti-inflammatory effects in vitro and in vivo.

Abstract

In this study, the furofuran lignan (+)-diayangambin [tetrahydro-1,4-bis(3,4,5-trimethoxyphenyl)-(1 R)-1alpha,3abeta,4alpha,6abeta-1 H,3 H-furo [3,4- c]furan] was evaluated in vitro and in vivo for its immunomodulatory and anti-inflammatory efficacy. Human mononuclear cell proliferation was inhibited by diayangambin with an IC 50 value of 1.5 (0.5 - 2.8) microM. In addition, the compound reduced for 40.8 % prostaglandin E 2 generation in stimulated RAW 264.7 macrophage cell line at 10 microM. In vivo, a clear reduction of ear swelling was observed when diayangambin (40 mg/kg) was administered orally to 2,4-dinitrofluorobenzene-treated mice. The inhibition of swelling was associated with a reduction of leukocyte infiltration determined as myeloperoxidase activity. In the carrageenan mouse paw edema model, diayangambin significantly suppressed inflamed paw volume and prostaglandin E 2 levels. Our findings indicate the potential interest of diayangambin in the treatment of immune and inflammatory responses.

• Authors: Elvira J De León, Dionisio A Olmedo, Pablo N Solís, Mahabir P Gupta, M Carmen Terencio
• Journal: Planta medica (Planta Med) Vol. 68 Issue 12 Pg. 1128-31 (Dec 2002) ISSN: 0032-0943 [Print] Germany
• PMID: 12494343 (Publication Type: Comparative Study, Letter, Research Support, Non-U.S. Gov't)

Chemical References

• Anisoles
• Anti-Inflammatory Agents, Non-Steroidal
• Furans
• Immunosuppressive Agents
• Plant Extracts
• diayangambin
• Dexamethasone
• Dinoprostone
• Azathioprine

Topics

• Animals
• Anisoles (chemistry, isolation & purification, pharmacology)
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology, therapeutic use)
• Azathioprine (pharmacology)
• Dexamethasone (pharmacology)
• Dinoprostone (metabolism)
• Disease Models, Animal
• Edema (drug therapy)
• Furans (chemistry, isolation & purification, pharmacology)
• Immunosuppressive Agents (pharmacology, therapeutic use)
• Inflammation (chemically induced, drug therapy)
• Lymphocyte Activation (drug effects)
• Macrophages (drug effects)
• Mice
• Molecular Structure
• Phytotherapy
• Piper
• Plant Extracts (chemistry, pharmacology, therapeutic use)