Abstract | OBJECTIVES: MATERIALS AND METHODS: The study was a two-centre, randomised, double-blind, parallel-group clinical trial, and consisted of a 2-week pre-experimental phase, followed by an experimental period of 6 months. A total of 140 healthy male and female volunteers (70 per group) who had at least 20 natural teeth with no probing depths greater than 5 mm and a mean gingival index (GI) of 1 or more at screening were admitted to the study. The two products were the test toothpaste (RCP) containing 0.5% SCN- ( rhodanide), carbamide peroxide (equivalent 0.1% H2O2), and 1450 p.p.m. fluoride, and a control toothpaste ( Colgate Total) containing 0.3% triclosan, 2.0% polyvinyl methyl ether maleic acid (PVM/MA), and 1450 p.p.m. fluoride ( Triclosan). In the pre-experimental phase, all subjects used a fluoride toothpaste. Plaque (Turesky et al. 1970) and gingivitis (Löe & Silness 1963) were scored prior to beginning the pre-experimental phase, at baseline, and after 6 weeks and 3 and 6 months. RESULTS: In both the RCP and the Triclosan group, gingival health improved significantly between baseline and the following examinations. Plaque scores decreased significantly between baseline and 6 months in both groups. There were, however, no significant differences between the groups for either gingival index or plaque index. CONCLUSION: To conclude, this study seems to verify that in normal home use, a toothpaste containing a combination of thiocyanate and carbamide peroxide is as effective in reducing gingival inflammation and supragingival plaque formation as a benchmark control product.
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Authors | Michael Rosin, Axel Kramer, Detlef Bradtke, Gerrit Richter, Thomas Kocher |
Journal | Journal of clinical periodontology
(J Clin Periodontol)
Vol. 29
Issue 12
Pg. 1086-91
(Dec 2002)
ISSN: 0303-6979 [Print] United States |
PMID | 12492909
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Anti-Infective Agents, Local
- Complex Mixtures
- Dentifrices
- Drug Combinations
- Peroxides
- Thiocyanates
- Toothpastes
- hydrated silica gel-based toothpaste
- Silicic Acid
- Carbamide Peroxide
- Triclosan
- Urea
- Fluorides
- potassium thiocyanate
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Topics |
- Adult
- Analysis of Variance
- Anti-Infective Agents, Local
(therapeutic use)
- Carbamide Peroxide
- Complex Mixtures
- Dental Plaque
(prevention & control)
- Dental Plaque Index
- Dentifrices
(therapeutic use)
- Double-Blind Method
- Drug Combinations
- Female
- Fluorides
- Gingivitis
(prevention & control)
- Humans
- Male
- Observer Variation
- Oral Hygiene
(methods)
- Periodontal Index
- Peroxides
(therapeutic use)
- Reproducibility of Results
- Silicic Acid
- Thiocyanates
(therapeutic use)
- Toothpastes
(chemistry, therapeutic use)
- Triclosan
(therapeutic use)
- Urea
(analogs & derivatives, therapeutic use)
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