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The effect of a SCN-/H2O2 toothpaste compared to a commercially available triclosan-containing toothpaste on oral hygiene and gingival health -- a 6-month home-use study.

AbstractOBJECTIVES:
The aim of the study was to compare the gingival health benefits of a thiocyanate/carbamide peroxide toothpaste to that of a triclosan toothpaste in home use.
MATERIALS AND METHODS:
The study was a two-centre, randomised, double-blind, parallel-group clinical trial, and consisted of a 2-week pre-experimental phase, followed by an experimental period of 6 months. A total of 140 healthy male and female volunteers (70 per group) who had at least 20 natural teeth with no probing depths greater than 5 mm and a mean gingival index (GI) of 1 or more at screening were admitted to the study. The two products were the test toothpaste (RCP) containing 0.5% SCN- (rhodanide), carbamide peroxide (equivalent 0.1% H2O2), and 1450 p.p.m. fluoride, and a control toothpaste (Colgate Total) containing 0.3% triclosan, 2.0% polyvinyl methyl ether maleic acid (PVM/MA), and 1450 p.p.m. fluoride (Triclosan). In the pre-experimental phase, all subjects used a fluoride toothpaste. Plaque (Turesky et al. 1970) and gingivitis (Löe & Silness 1963) were scored prior to beginning the pre-experimental phase, at baseline, and after 6 weeks and 3 and 6 months.
RESULTS:
In both the RCP and the Triclosan group, gingival health improved significantly between baseline and the following examinations. Plaque scores decreased significantly between baseline and 6 months in both groups. There were, however, no significant differences between the groups for either gingival index or plaque index.
CONCLUSION:
To conclude, this study seems to verify that in normal home use, a toothpaste containing a combination of thiocyanate and carbamide peroxide is as effective in reducing gingival inflammation and supragingival plaque formation as a benchmark control product.
AuthorsMichael Rosin, Axel Kramer, Detlef Bradtke, Gerrit Richter, Thomas Kocher
JournalJournal of clinical periodontology (J Clin Periodontol) Vol. 29 Issue 12 Pg. 1086-91 (Dec 2002) ISSN: 0303-6979 [Print] United States
PMID12492909 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Anti-Infective Agents, Local
  • Complex Mixtures
  • Dentifrices
  • Drug Combinations
  • Peroxides
  • Thiocyanates
  • Toothpastes
  • hydrated silica gel-based toothpaste
  • Silicic Acid
  • Carbamide Peroxide
  • Triclosan
  • Urea
  • Fluorides
  • potassium thiocyanate
Topics
  • Adult
  • Analysis of Variance
  • Anti-Infective Agents, Local (therapeutic use)
  • Carbamide Peroxide
  • Complex Mixtures
  • Dental Plaque (prevention & control)
  • Dental Plaque Index
  • Dentifrices (therapeutic use)
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Fluorides
  • Gingivitis (prevention & control)
  • Humans
  • Male
  • Observer Variation
  • Oral Hygiene (methods)
  • Periodontal Index
  • Peroxides (therapeutic use)
  • Reproducibility of Results
  • Silicic Acid
  • Thiocyanates (therapeutic use)
  • Toothpastes (chemistry, therapeutic use)
  • Triclosan (therapeutic use)
  • Urea (analogs & derivatives, therapeutic use)

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