Abstract | BACKGROUND: METHOD: A 5-step double blind, crossover experimental gingivitis study was conducted on 19 volunteers during a 21-day period. The volunteers refrained from brushing an experimental quadrant of teeth. The dentifrices were applied to those teeth via toothshield three times per day; simultaneously they brushed the other teeth with the same dentifrice. After each period, VSCs in mouth air and BAPNA hydrolysis by dental plaque accumulated in the experimental quadrant were determined. RESULTS: There was an increase (p < 0.05) in VSCs in mouth air when experimental gingivitis was induced in only one quadrant of teeth. None of the dentifrices was able to avoid the increase of VSCs during the experimental gingivitis development. The majority of the antiplaque dentifrices evaluated reduced the increase of VSC formation in comparison with the control (p < 0.05). There was no relationship between the ability of the dentifrices in reducing VSC formation and the inhibition of trypsin-like activity in dental plaque. CONCLUSIONS: Anti-plaque dentifrices reduce the increase of VSCs that occurs during the development of experimental gingivitis.
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Authors | G R Nogueira-Filho, P M Duarte, S Toledo, C P M Tabchoury, J A Cury |
Journal | Journal of clinical periodontology
(J Clin Periodontol)
Vol. 29
Issue 12
Pg. 1059-64
(Dec 2002)
ISSN: 0303-6979 [Print] United States |
PMID | 12492904
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents
- Dentifrices
- Sulfur Compounds
- Triclosan
- Benzoylarginine Nitroanilide
- Trypsin
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Topics |
- Adult
- Analysis of Variance
- Anti-Infective Agents
(administration & dosage, therapeutic use)
- Benzoylarginine Nitroanilide
- Breath Tests
- Cross-Over Studies
- Dental Plaque
(drug therapy, enzymology)
- Dentifrices
(therapeutic use)
- Double-Blind Method
- Female
- Gingivitis
(metabolism)
- Halitosis
(prevention & control)
- Humans
- Male
- Statistics, Nonparametric
- Sulfur Compounds
(metabolism)
- Triclosan
(administration & dosage, therapeutic use)
- Trypsin
(metabolism)
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