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Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement.

AuthorsShimon Ben-Shabat, Yasuhiro Itagaki, Steffen Jockusch, Janet R Sparrow, Nicholas J Turro, Koji Nakanishi
JournalAngewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 41 Issue 5 Pg. 814-7 (Mar 01 2002) ISSN: 1433-7851 [Print] Germany
PMID12491345 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • A2-E (N-retinylidene-N-retinylethanolamine)
  • Alkenes
  • Epoxy Compounds
  • Lipofuscin
  • Pyridinium Compounds
  • Radiation-Sensitizing Agents
  • Retinoids
  • nonaoxirane
  • Singlet Oxygen
  • Ethylene Oxide
Topics
  • Alkenes (chemistry)
  • Animals
  • Epoxy Compounds
  • Ethylene Oxide (analogs & derivatives, chemistry)
  • Humans
  • Light
  • Lipofuscin (chemistry)
  • Macular Degeneration (etiology)
  • Photochemistry
  • Pyridinium Compounds (chemistry, radiation effects)
  • Radiation-Sensitizing Agents
  • Retinoids (chemistry, radiation effects)
  • Singlet Oxygen

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