HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Chronic intestinal inflammation and angiogenesis in genetically susceptible rats is modulated by kininogen deficiency.

Abstract
Genetically susceptible Lewis rats injected in the intestinal wall with peptidoglycan-polysaccharide (PG-APS) polymers develop chronic granulomatous enterocolitis associated with activation of the kallikrein-kinin system. To elucidate the role of high-molecular-weight kininogen (HK), we backcrossed Brown Norway rats having an HK deficiency with Lewis rats for five generations. Two new strains were produced, wild-type F5 (F5WT) and HK deficient (F5HKd), each with a approximately 97% Lewis genome. The HK values of F5WT rat plasma and F5HKd rat plasma were 0.62 +/- 0.20 and 0.08 +/- 0.03 U/ml, respectively. Among the inflammatory changes, the mean gross gut, total intestinal histologic and liver granuloma score and the white blood count were significantly lower in the F5HKd than the F5WT rats. Plasma T-kininogen was significantly less in F5HKd. Angiogenesis (mean vascular density) in the cecum was decreased significantly in F5HKd compared to F5WT. These results indicate the importance of the kallikrein-kinin system in this model of chronic enterocolitis and systemic inflammation.
AuthorsIrma Isordia-Salas, Robin A Pixley, Fengling Li, Irma Sainz, R Balfour Sartor, Albert Adam, Robert W Colman
JournalInternational immunopharmacology (Int Immunopharmacol) Vol. 2 Issue 13-14 Pg. 1895-905 (Dec 2002) ISSN: 1567-5769 [Print] Netherlands
PMID12489803 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Kininogen, High-Molecular-Weight
Topics
  • Animals
  • Base Sequence
  • Cecum (blood supply)
  • Enterocolitis (genetics, physiopathology)
  • Genetic Predisposition to Disease
  • Granulomatous Disease, Chronic (genetics, physiopathology)
  • Kallikrein-Kinin System (genetics, physiology)
  • Kininogen, High-Molecular-Weight (blood, deficiency, genetics)
  • Molecular Sequence Data
  • Neovascularization, Physiologic (genetics, physiology)
  • Rats
  • Rats, Inbred Lew

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: