Germinoma with a granulomatous reaction. Problems of differential diagnosis.

Abstract

The patient was a 6 year-old girl with a progressive loss of visual acuity. Magnetic resonance imaging showed a suprasellar mass lesion with enhanced gadolinium which was resected. Histopathological study showed a remarkable granulomatous reaction, but a diagnosis was difficult. However, immunohistochemical study showed a few cells that were positive for placental alkaline phosphatase and it was diagnosed as germinoma. Intracranial germinoma with a remarkable granulomatous reaction is rare. However, when germinoma is suspected clinically, an immunohistochemical study is able to identify germinoma even if granulomatous disease is diagnosed histopathologically.

• Authors: S Konno, H Oka, S Utsuki, K Kondou, S Tanaka, K Fujii, S Yagishita
• Journal: Clinical neuropathology (Clin Neuropathol) 2002 Nov-Dec Vol. 21 Issue 6 Pg. 248-51 ISSN: 0722-5091 [Print] Germany
• PMID: 12489672 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• GPI-Linked Proteins
• Isoenzymes
• Etoposide
• Alkaline Phosphatase
• alkaline phosphatase, placental
• Cisplatin

Topics

• Alkaline Phosphatase
• Antineoplastic Agents (therapeutic use)
• Brain Neoplasms (diagnosis, metabolism, pathology, radiotherapy, surgery)
• Child
• Cisplatin (therapeutic use)
• Diagnosis, Differential
• Etoposide (therapeutic use)
• Female
• GPI-Linked Proteins
• Germinoma (diagnosis, metabolism, pathology, radiotherapy, surgery)
• Granuloma (diagnosis, metabolism, pathology, radiotherapy, surgery)
• Humans
• Immunohistochemistry
• Isoenzymes (metabolism)
• Magnetic Resonance Imaging