Abstract |
The patient was a 6 year-old girl with a progressive loss of visual acuity. Magnetic resonance imaging showed a suprasellar mass lesion with enhanced gadolinium which was resected. Histopathological study showed a remarkable granulomatous reaction, but a diagnosis was difficult. However, immunohistochemical study showed a few cells that were positive for placental alkaline phosphatase and it was diagnosed as germinoma. Intracranial germinoma with a remarkable granulomatous reaction is rare. However, when germinoma is suspected clinically, an immunohistochemical study is able to identify germinoma even if granulomatous disease is diagnosed histopathologically.
|
Authors | S Konno, H Oka, S Utsuki, K Kondou, S Tanaka, K Fujii, S Yagishita |
Journal | Clinical neuropathology
(Clin Neuropathol)
2002 Nov-Dec
Vol. 21
Issue 6
Pg. 248-51
ISSN: 0722-5091 [Print] Germany |
PMID | 12489672
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Antineoplastic Agents
- GPI-Linked Proteins
- Isoenzymes
- Etoposide
- Alkaline Phosphatase
- alkaline phosphatase, placental
- Cisplatin
|
Topics |
- Alkaline Phosphatase
- Antineoplastic Agents
(therapeutic use)
- Brain Neoplasms
(diagnosis, metabolism, pathology, radiotherapy, surgery)
- Child
- Cisplatin
(therapeutic use)
- Diagnosis, Differential
- Etoposide
(therapeutic use)
- Female
- GPI-Linked Proteins
- Germinoma
(diagnosis, metabolism, pathology, radiotherapy, surgery)
- Granuloma
(diagnosis, metabolism, pathology, radiotherapy, surgery)
- Humans
- Immunohistochemistry
- Isoenzymes
(metabolism)
- Magnetic Resonance Imaging
|