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Pretargeted radioimmunotherapy (PRIT) using an antibody-streptavidin fusion protein in non-Hodgkin's lymphoma.

Abstract
Pretargeted radioimmunotherapy (PRIT) decreases the amount of time that radioactivity non-selectively circulates. Our PRIT approach is a multi-step method in which a monoclonal antibody is used to target streptavidin to a tumor-associated antigen and biotin is then used to target 90Y to the streptavidin. A genetically engineered antibody streptavidin fusion construct was used to target tumor in a patient with non-Hodgkin's lymphoma. Impressive localization of 90Y to known and previously unknown areas of adenopathy was observed, thus demonstrating that a genetically engineered fusion protein can selectively target lymphoma cells as part of a clinically meaningful PRIT strategy.
AuthorsPaul L Weiden
JournalLeukemia & lymphoma (Leuk Lymphoma) Vol. 43 Issue 10 Pg. 1971-3 (Oct 2002) ISSN: 1042-8194 [Print] United States
PMID12481894 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Antibodies, Neoplasm
  • Immunoconjugates
  • Indium Radioisotopes
  • Recombinant Fusion Proteins
  • Yttrium Radioisotopes
  • Biotin
  • Rhenium
  • Streptavidin
Topics
  • Antibodies, Monoclonal (therapeutic use)
  • Antibodies, Neoplasm (therapeutic use)
  • Biotin
  • Female
  • Humans
  • Immunoconjugates (administration & dosage, pharmacokinetics, therapeutic use)
  • Indium Radioisotopes (administration & dosage, therapeutic use)
  • Lymphoma, Non-Hodgkin (radiotherapy)
  • Middle Aged
  • Radioimmunotherapy (methods)
  • Recombinant Fusion Proteins (administration & dosage, pharmacokinetics, therapeutic use)
  • Rhenium (administration & dosage, therapeutic use)
  • Streptavidin
  • Tissue Distribution
  • Yttrium Radioisotopes (administration & dosage, therapeutic use)

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