Abstract |
Here, we investigated the effects of sympathectomy on systemic bacterial loads following infection with Listeria monocytogenes, and on innate and specific immune responses in the peritoneum. Sympathectomy decreased systemic bacterial loads, and increased the number of peritoneal leukocytes and the percentage of peritoneal macrophages three days postinfection. This suggests that sympathectomy-induced decreases systemic bacterial loads are associated with increased recruitment of inflammatory cells into tissues during the innate immune response.
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Authors | P A Rice, G W Boehm, J A Moynihan, D L Bellinger, S Y Stevens |
Journal | Brain, behavior, and immunity
(Brain Behav Immun)
Vol. 16
Issue 6
Pg. 654-62
(Dec 2002)
ISSN: 0889-1591 [Print] Netherlands |
PMID | 12480496
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Sympatholytics
- Interferon-gamma
- Oxidopamine
- Norepinephrine
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Topics |
- Animals
- Interferon-gamma
(blood)
- Listeriosis
(immunology)
- Macrophages, Peritoneal
(cytology, microbiology)
- Male
- Mice
- Mice, Inbred BALB C
- Norepinephrine
(metabolism)
- Oxidopamine
- Peritoneum
(immunology, innervation)
- Peritonitis
(immunology, microbiology)
- Phagocytes
(cytology, microbiology)
- Spleen
(immunology, metabolism)
- Sympathectomy, Chemical
- Sympatholytics
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