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Chemical sympathectomy increases numbers of inflammatory cells in the peritoneum early in murine listeriosis.

Abstract
Here, we investigated the effects of sympathectomy on systemic bacterial loads following infection with Listeria monocytogenes, and on innate and specific immune responses in the peritoneum. Sympathectomy decreased systemic bacterial loads, and increased the number of peritoneal leukocytes and the percentage of peritoneal macrophages three days postinfection. This suggests that sympathectomy-induced decreases systemic bacterial loads are associated with increased recruitment of inflammatory cells into tissues during the innate immune response.
AuthorsP A Rice, G W Boehm, J A Moynihan, D L Bellinger, S Y Stevens
JournalBrain, behavior, and immunity (Brain Behav Immun) Vol. 16 Issue 6 Pg. 654-62 (Dec 2002) ISSN: 0889-1591 [Print] Netherlands
PMID12480496 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Sympatholytics
  • Interferon-gamma
  • Oxidopamine
  • Norepinephrine
Topics
  • Animals
  • Interferon-gamma (blood)
  • Listeriosis (immunology)
  • Macrophages, Peritoneal (cytology, microbiology)
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Norepinephrine (metabolism)
  • Oxidopamine
  • Peritoneum (immunology, innervation)
  • Peritonitis (immunology, microbiology)
  • Phagocytes (cytology, microbiology)
  • Spleen (immunology, metabolism)
  • Sympathectomy, Chemical
  • Sympatholytics

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