Abstract | PURPOSE: MATERIALS AND METHODS: From 1994 to 1999, 19 children and 6 adults with myelomeningocele underwent periurethral injections of collagen with an average of 2 treatments per patient. Mean followup +/- SD from last injection in the pediatric and adult groups was 2.9 +/- 1.5 years and 4.7 +/- 2.6 years, respectively. Postoperative continence was defined as dry, improved or unchanged. RESULTS: No pediatric patients became dry, 7 (37%) improved and 12 (63%) were unchanged. A single adult was dry (17%), 4 (67%) improved and 1 remained unchanged. Transient improvement was noted in 8 of the 13 patients who reverted to an unchanged status. Response rate was 66% in nonambulatory patients versus 42% in ambulatory patients (p = 0.38). Of 12 patients who responded and 13 who did not 8 in each group required 2 or more treatments. The responding group percentage of predicted bladder capacity was 97.6% versus 89.5% in those who remained unchanged (p = 0.66). CONCLUSIONS: The initial transient improvement following collagen injection and the long-term improvement following repeat injections suggest that degradation of collagen decreased its efficacy. The long-term results of this minimally invasive technique are poor.
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Authors | Craig A Block, Christopher S Cooper, Charles E Hawtrey |
Journal | The Journal of urology
(J Urol)
Vol. 169
Issue 1
Pg. 327-9
(Jan 2003)
ISSN: 0022-5347 [Print] United States |
PMID | 12478183
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Child
- Collagen
(administration & dosage)
- Female
- Follow-Up Studies
- Humans
- Injections
- Male
- Meningomyelocele
(complications)
- Treatment Outcome
- Urethra
- Urinary Incontinence
(etiology, therapy)
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