Abstract | PURPOSE: METHODS: RESULTS: Independent from the anesthesia regimen chosen, dolasetron reduced PONV (19%) significantly compared to MCP (45%) and placebo (46%). Furthermore we could show a significant difference in the incidence of PONV between IVA (28%) and isoflurane (46%), but not in comparison to desflurane (36%). Patients receiving IVA had a higher postoperative piritramide consumption compared to the two other groups. CONCLUSIONS: The results of our study suggest that dolasetron was more effective than MCP and placebo in preventing PONV. This action is independent of the anesthetic technique used.
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Authors | Swen N Piper, Stefan W Suttner, Kerstin D Röhm, Wolfgang H Maleck, Eberhard Larbig, Joachim Boldt |
Journal | Canadian journal of anaesthesia = Journal canadien d'anesthesie
(Can J Anaesth)
Vol. 49
Issue 10
Pg. 1021-8
(Dec 2002)
ISSN: 0832-610X [Print] United States |
PMID | 12477671
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Retracted Publication)
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Chemical References |
- Antiemetics
- Indoles
- Quinolizines
- Serotonin Antagonists
- dolasetron
- Metoclopramide
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Topics |
- Adult
- Aged
- Anesthesia, Inhalation
- Anesthesia, Intravenous
- Antiemetics
(therapeutic use)
- Cholecystectomy, Laparoscopic
- Double-Blind Method
- Female
- Humans
- Indoles
(therapeutic use)
- Male
- Metoclopramide
(therapeutic use)
- Middle Aged
- Postoperative Nausea and Vomiting
(prevention & control)
- Quinolizines
(therapeutic use)
- Serotonin Antagonists
(therapeutic use)
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