Abstract |
Finasteride 1 mg/day is effective in the treatment of androgenetic alopecia (AGA). Our open-label study assessed the efficacy and safety of finasteride for the treatment of Taiwanese men with AGA. We enrolled 34 Taiwanese men (aged 18-40 yr) with AGA of modified Norwood/Hamilton scale (MNHS) grade II-V. In investigator assessments at 12 months, five of 21 subjects (23.8%) had two-grade improvement in MNHS grade and 12 of 21 subjects (57.1%) had one-grade improvement; the others remained at the same grade. In global photographic evaluation, five of 31 subjects (15.1%) had observable hair growth at 6 months and 11 of 21 subjects (52.4%) had observable hair growth at 12 months. Patient self-assessment of hair growth was favorable across all questions in the treatment course, more significantly at 12 months than at 6 months; nine of 21 subjects (42.9%) were satisfied with their overall appearance at 12 months. Serum prostate specific antigen levels had decreased by 23.4% at 12 months. Adverse effects, including abnormal liver function (5/34), were minimal, and the causal relationship with finasteride could not be established. Thus, in Taiwanese men with AGA, finasteride 1 mg/day for 1 year slowed the progression of hair loss and increased hair growth.
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Authors | Jeng-Hsien Lin, Wen-Chieh Chen |
Journal | The Kaohsiung journal of medical sciences
(Kaohsiung J Med Sci)
Vol. 18
Issue 8
Pg. 379-85
(Aug 2002)
ISSN: 1607-551X [Print] China (Republic : 1949- ) |
PMID | 12476680
(Publication Type: Journal Article)
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Chemical References |
- Enzyme Inhibitors
- Finasteride
- Prostate-Specific Antigen
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Topics |
- Adolescent
- Adult
- Alopecia
(drug therapy)
- Enzyme Inhibitors
(therapeutic use)
- Finasteride
(adverse effects, therapeutic use)
- Humans
- Liver
(drug effects)
- Male
- Prostate-Specific Antigen
(blood)
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