Human herpesvirus-7 infection of the CNS with acute myelitis in an adult bone marrow recipient.

Abstract

The beta-herpesviruses, human herpesviruses-6 and -7 (HHV-6 and HHV-7), are closely related and have very similar biological behaviour. While HHV-6 is associated with encephalitis in immunosuppressed adults, HHV-7 is not recognised as a cause of neurological disease in such patients. This report describes the identification of a reactivated HHV-7 infection in the cerebrospinal fluid of an adult who presented with an acute myelitis 11 months after unrelated donor bone marrow transplant.

• Authors: K N Ward, R P White, S Mackinnon, M Hanna
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 30 Issue 12 Pg. 983-5 (Dec 2002) ISSN: 0268-3369 [Print] England
• PMID: 12476296 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Immunosuppressive Agents
• Methylprednisolone

Topics

• Anti-Inflammatory Agents (therapeutic use)
• Bone Marrow Transplantation (adverse effects)
• Cerebrospinal Fluid (virology)
• Graft vs Host Disease (drug therapy, etiology)
• Herpesvirus 7, Human (growth & development, isolation & purification)
• Humans
• Immunocompromised Host
• Immunosuppressive Agents (adverse effects)
• Lymphocyte Transfusion
• Male
• Methylprednisolone (therapeutic use)
• Middle Aged
• Multiple Myeloma (complications, therapy)
• Myelitis (drug therapy, etiology, virology)
• Paraparesis, Spastic (drug therapy, etiology, virology)
• Roseolovirus Infections (etiology)
• Transplantation, Homologous (adverse effects)
• Urinary Bladder, Neurogenic (etiology)
• Virus Activation