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Clinical significance of myocardial magnetic resonance abnormalities in patients with sarcoidosis: a 1-year follow-up study.

AbstractPURPOSE:
To assess the follow-up of patients with sarcoidosis and myocardial MRI abnormalities.
MATERIALS AND METHODS:
Twelve patients with histologically proven sarcoidosis and highly suspected cardiac involvement underwent initial and 12-month follow-up cardiac assessment including cardiac MRI (T2-weighted, functional gradient echo, and T1-weighted gadolinium-diethylenetriamine penta-acetic acid-enhanced sequences). MRI abnormalities and clinical and MRI progression were scored by two observers.
RESULTS:
Six patients receiving corticosteroid therapy (including three patients with clinical cardiac involvement) were scored as having cleared or improved at MRI follow-up, while others were seen to have worsened or remained stable. The stability, improvement, or clearing of MRI findings were correlated with clinically stable, improved or cleared sarcoidosis, while a worsening at MRI follow-up was correlated with a worsening of sarcoidosis and, in one patient, was predictive of clinical cardiac involvement.
CONCLUSION:
Cardiac MRI is a useful noninvasive method for the early diagnosis and follow-up of cardiac sarcoidosis.
AuthorsOlivier Vignaux, Robin Dhote, Denis Duboc, Philippe Blanche, Daniel Dusser, Simon Weber, Paul Legmann
JournalChest (Chest) Vol. 122 Issue 6 Pg. 1895-901 (Dec 2002) ISSN: 0012-3692 [Print] United States
PMID12475823 (Publication Type: Journal Article)
Chemical References
  • Adrenal Cortex Hormones
  • Pentetic Acid
Topics
  • Adrenal Cortex Hormones (therapeutic use)
  • Adult
  • Female
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging (methods)
  • Male
  • Middle Aged
  • Myocardium (pathology)
  • Pentetic Acid
  • Sarcoidosis (diagnosis, drug therapy)

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