Abstract | PURPOSE: To assess the follow-up of patients with sarcoidosis and myocardial MRI abnormalities. MATERIALS AND METHODS: Twelve patients with histologically proven sarcoidosis and highly suspected cardiac involvement underwent initial and 12-month follow-up cardiac assessment including cardiac MRI (T2-weighted, functional gradient echo, and T1-weighted gadolinium- diethylenetriamine penta- acetic acid-enhanced sequences). MRI abnormalities and clinical and MRI progression were scored by two observers. RESULTS: Six patients receiving corticosteroid therapy (including three patients with clinical cardiac involvement) were scored as having cleared or improved at MRI follow-up, while others were seen to have worsened or remained stable. The stability, improvement, or clearing of MRI findings were correlated with clinically stable, improved or cleared sarcoidosis, while a worsening at MRI follow-up was correlated with a worsening of sarcoidosis and, in one patient, was predictive of clinical cardiac involvement. CONCLUSION: Cardiac MRI is a useful noninvasive method for the early diagnosis and follow-up of cardiac sarcoidosis.
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Authors | Olivier Vignaux, Robin Dhote, Denis Duboc, Philippe Blanche, Daniel Dusser, Simon Weber, Paul Legmann |
Journal | Chest
(Chest)
Vol. 122
Issue 6
Pg. 1895-901
(Dec 2002)
ISSN: 0012-3692 [Print] United States |
PMID | 12475823
(Publication Type: Journal Article)
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Chemical References |
- Adrenal Cortex Hormones
- Pentetic Acid
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Topics |
- Adrenal Cortex Hormones
(therapeutic use)
- Adult
- Female
- Follow-Up Studies
- Humans
- Magnetic Resonance Imaging
(methods)
- Male
- Middle Aged
- Myocardium
(pathology)
- Pentetic Acid
- Sarcoidosis
(diagnosis, drug therapy)
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