Effect of weight loss on VLDL-triglyceride and apoB-100 kinetics in women with abdominal obesity.

• Abstract: The effects of obesity and weight loss on lipoprotein kinetics were evaluated in six lean women [body mass index (BMI): 21 +/- 1 kg/m(2)] and seven women with abdominal obesity (BMI: 36 +/- 1 kg/m(2)). Stable isotope tracer techniques, in conjunction with compartmental modeling, were used to determine VLDL-triglyceride (TG) and apolipoprotein B-100 (apoB-100) secretion rates in lean women and in obese women before and after 10% weight loss. VLDL-TG and VLDL-apoB-100 secretion rates were similar in lean and obese women. Weight loss decreased the rate of VLDL-TG secretion by approximately 40% (from 0.41 +/- 0.05 to 0.23 +/- 0.03 micromol x kg fat-free mass(-1) x min(-1); P < 0.05). The relative decline in VLDL-TG produced from nonsystemic fatty acids, derived from intraperitoneal and intrahepatic TG, was greater (61 +/- 7%) than the decline in VLDL-TG produced from systemic fatty acids, predominantly derived from subcutaneous TG (25 +/- 8%; P < 0.05). Weight loss did not affect VLDL-apoB-100 secretion rate. We conclude that weight loss decreases the rate of VLDL-TG secretion in women with abdominal obesity, primarily by decreasing the availability of nonsystemic fatty acids. There is a dissociation in the effect of weight loss on VLDL-TG and apoB-100 metabolic pathways that may affect VLDL particle size.
• Authors: Bettina Mittendorfer, Bruce W Patterson, Samuel Klein (Affiliation: Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri 63110, USA.)
• Journal: American journal of physiology. Endocrinology and metabolism (Am J Physiol Endocrinol Metab) Vol. 284 Issue 3 Pg. E549-56 (Mar 2003) ISSN: 0193-1849 [Print] United States
• PMID: 12475754 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Apolipoprotein B-100
• Apolipoproteins B
• Fatty Acids
• Lipids
• Lipoproteins, VLDL
• Triglycerides
• very low density lipoprotein triglyceride
• Insulin

Topics

• Abdomen
• Adult
• Apolipoprotein B-100
• Apolipoproteins B (metabolism)
• Body Composition
• Fatty Acids (metabolism)
• Female
• Humans
• Insulin (blood)
• Kinetics
• Lipids (blood)
• Lipoproteins, VLDL (metabolism)
• Obesity (pathology, physiopathology)
• Osmolar Concentration
• Triglycerides (metabolism)
• Weight Loss