HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Burning mouth syndrome (BMS): an open trial of comparative efficacy of alpha-lipoic acid (thioctic acid) with other therapies.

AbstractBACKGROUND:
Alpha-lipoic acid (ALA) is a potent antioxidant mitochondrial coenzyme, trometamol salt of thioctic acid, shown in clinical studies to be neuroprotective and in a preliminary study to have an effect on the symptomatology of Burning Mouth Syndrome (BMS).
METHODS:
We were interested in extending our studies as to whether alpha-lipoic acid might improve the symptomatology in BMS and therefore carried out a larger open controlled clinical study on the effects of alpha-lipoic acid on BMS symptomatology.
RESULTS:
We have examined the effects on 4 groups of 20 patients with BMS of ALA, compared with bethanecol, Biotene and placebo, and found ALA of remarkable benefit with minimal adverse effects.
CONCLUSIONS:
These results suggest that double-blind randomized controlled multicenter studies of ALA are indicated.
AuthorsF Femiano
JournalMinerva stomatologica (Minerva Stomatol) Vol. 51 Issue 9 Pg. 405-9 (Sep 2002) ISSN: 0026-4970 [Print] Italy
PMID12473978 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Biotene
  • Drug Combinations
  • Mouthwashes
  • Neuroprotective Agents
  • Bethanechol
  • Thioctic Acid
  • Glucose Oxidase
  • Lactoperoxidase
  • Muramidase
  • Xylitol
Topics
  • Administration, Oral
  • Adult
  • Aged
  • Bethanechol (therapeutic use)
  • Burning Mouth Syndrome (drug therapy)
  • Cohort Studies
  • Drug Combinations
  • Female
  • Glucose Oxidase (therapeutic use)
  • Humans
  • Lactoperoxidase (therapeutic use)
  • Male
  • Middle Aged
  • Mouthwashes (therapeutic use)
  • Muramidase (therapeutic use)
  • Neuroprotective Agents (therapeutic use)
  • Thioctic Acid (therapeutic use)
  • Treatment Outcome
  • Xylitol (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: