Abstract | BACKGROUND: METHODS: RESULTS: Preoperative CEA and CA19.9 levels were increased in, respectively, 75% and 58% of the patients. Baseline tumor marker values were related to the extent of tumor. Immediately after HIPEC, both tumor markers decreased markedly (P <.0001). CA19.9 was shown to be a more useful tumor marker than CEA for follow-up. During follow-up, a high absolute CA19.9 level (P =.0005) was predictive for imminent recurrence. Patients who never attained a normal CA19.9 level showed a higher recurrence rate at 1 year (53%; SE, 15%), in comparison to patients who did so (6%; SE 4%). The median lead time of increased CA19.9 to recurrence was 9 months. CONCLUSIONS:
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Authors | S van Ruth, A A M Hart, J M G Bonfrer, V J Verwaal, F A N Zoetmulder |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 9
Issue 10
Pg. 961-7
(Dec 2002)
ISSN: 1068-9265 [Print] United States |
PMID | 12464587
(Publication Type: Journal Article)
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Chemical References |
- CA-19-9 Antigen
- Carcinoembryonic Antigen
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Topics |
- Analysis of Variance
- CA-19-9 Antigen
(metabolism)
- Carcinoembryonic Antigen
(metabolism)
- Disease-Free Survival
- Humans
- Netherlands
(epidemiology)
- Peritoneal Neoplasms
(diagnosis, mortality, therapy)
- Predictive Value of Tests
- Prognosis
- Proportional Hazards Models
- Pseudomyxoma Peritonei
(diagnosis, mortality, therapy)
- Recurrence
- Survival Rate
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