Therapy of peptic ulcer with semax peptide.

Abstract

Experiments used is combination with traditional preparations (omeprasole, de-nol, and solcoseril), Semax peptide (Met-Glu-His-Phe-Pro-Gly-Pro) possessing nootropic and neuroprotective activity significantly promoted ulcer healing in patients with refractory peptic ulcers. On day 14 of treatment ulcer healing was observed in 89.5% patients receiving intranasal Semax (1% solution, 2-4 drops 3 times a day for 10 days) vs. 30.8% in the control group. Clinical studies of antiulcer activity of Semax in different combinations with usual antiulcer drugs are needed.

• Authors: I O Ivanikov, M E Brekhova, G E Samonina, N F Myasoedov, I P Ashmarin
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 134 Issue 1 Pg. 73-4 (Jul 2002) ISSN: 0007-4888 [Print] United States
• PMID: 12459874 (Publication Type: Journal Article)

Chemical References

• Neuroprotective Agents
• Nootropic Agents
• Peptide Fragments
• ACTH (4-7), Pro-Gly-Pro-
• Adrenocorticotropic Hormone

Topics

• Adrenocorticotropic Hormone (analogs & derivatives, therapeutic use)
• Aged
• Aged, 80 and over
• Female
• Humans
• Male
• Middle Aged
• Neuroprotective Agents (therapeutic use)
• Nootropic Agents (therapeutic use)
• Peptic Ulcer (drug therapy)
• Peptide Fragments (therapeutic use)
• Time Factors
• Treatment Outcome