Abstract | RATIONALE: OBJECTIVE: The purpose of this study was to determine the occupancy of the SERT achieved in vivo by the SSRI paroxetine in social phobia patients at typical antianxiety doses. METHODS: Measures of SERT availability were obtained with positron emission tomography and the SERT radiotracer [(11)C](+)- McN 5652 in five patients with social phobia before and during treatment with paroxetine at usual therapeutic doses (20-40 mg per day). RESULTS: Occupancy of the SERT by paroxetine was high in all subjects and in all regions measured after 3-6 months of continuous treatment. CONCLUSIONS: The results of this study in an anxiety disorder sample are consistent with previously reported results in a depressed sample and suggest that paroxetine at therapeutic doses achieves very high occupancy levels of the SERT.
|
Authors | Justine M Kent, Jeremy D Coplan, Ilise Lombardo, Dah-Ren Hwang, Yiyun Huang, Osama Mawlawi, Ronald L Van Heertum, Mark Slifstein, Anissa Abi-Dargham, Jack M Gorman, Marc Laruelle |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 164
Issue 4
Pg. 341-8
(Dec 2002)
ISSN: 0033-3158 [Print] Germany |
PMID | 12457263
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Carrier Proteins
- Isoquinolines
- Membrane Glycoproteins
- Membrane Transport Proteins
- Nerve Tissue Proteins
- SLC6A4 protein, human
- Serotonin Plasma Membrane Transport Proteins
- Serotonin Uptake Inhibitors
- Paroxetine
- McN 5652
|
Topics |
- Adult
- Brain
(diagnostic imaging, drug effects)
- Brain Mapping
- Carrier Proteins
(drug effects, physiology)
- Dose-Response Relationship, Drug
- Female
- Humans
- Image Processing, Computer-Assisted
- Isoquinolines
(pharmacokinetics)
- Magnetic Resonance Imaging
- Male
- Membrane Glycoproteins
(drug effects, physiology)
- Membrane Transport Proteins
- Middle Aged
- Nerve Tissue Proteins
- Paroxetine
(pharmacokinetics, therapeutic use)
- Personality Inventory
- Phobic Disorders
(diagnostic imaging, drug therapy)
- Serotonin Plasma Membrane Transport Proteins
- Selective Serotonin Reuptake Inhibitors
(pharmacokinetics, therapeutic use)
- Tomography, Emission-Computed
|