Efficacy and safety of almotriptan malate for migraine.

Abstract

The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of almotriptan are reviewed. Migraine is a common disorder with a serious impact on quality of life. Newer serotonin-receptor agonists have been developed with the aim of improving pharmacokinetic characteristics. Almotriptan, a selective agonist of serotonin receptors 1B and 1D, carries FDA-approved labeling for use in the management of migraine with or without aura in adults. The efficacy and receptor affinity resemble those of sumatriptan, but almotriptan has a more favorable pharmacokinetic profile. It has a rapid onset of action, an oral bioavailability of 70-80%, and a longer half-life than sumatriptan. In clinical trials, almotriptan has been significantly more effective than placebo and as effective as sumatriptan. However, it has been associated with better tolerability and greater patient satisfaction. In clinical trials, the most commonly reported adverse effects were nausea, dry mouth, dizziness, somnolence, fatigue, vomiting, and paresthesia. Almotriptan is contraindicated in patients with known ischemic heart disease, coronary vasospasm, and other significant cardiovascular disorders. Almotriptan has a lower acquisition cost than other triptans and possibly lower overall health care costs because of a lower frequency of cardiovascular adverse effects. The recommended dose of almotriptan is one 6.25- or 12.5-mg tablet given at the onset of symptoms. Almotriptan is effective for the management of migraine and offers the potential for fewer adverse effects than other agents in its class.

• Authors: Ebrahim A Balbisi
• Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists (Am J Health Syst Pharm) Vol. 59 Issue 22 Pg. 2184-93 (Nov 15 2002) ISSN: 1079-2082 [Print] England
• PMID: 12455302 (Publication Type: Journal Article, Review)

Chemical References

• Indoles
• Serotonin Receptor Agonists
• Tryptamines
• almotriptan

Topics

• Biological Availability
• Clinical Trials as Topic
• Drug Costs
• Drug Interactions
• Humans
• Indoles (economics, pharmacology, therapeutic use)
• Migraine Disorders (drug therapy)
• Product Surveillance, Postmarketing
• Serotonin Receptor Agonists (economics, pharmacology, therapeutic use)
• Tryptamines