Abstract | BACKGROUND: METHODS: This was a multicenteric, international, double-blind, randomized, placebo-controlled study. After the eight-week screening period, patients were randomized to receive daily ribavirin 1200 mg or placebo, during the 48-week treatment period. Follow-up observations were performed during a 16 week post-treatment period. Up to 80 male and female outpatients with mild to moderate chronic active hepatitis C virus infection were enrolled in this study. RESULTS: During the treatment period ALT values were significantly lower in the ribavirin group. Neither in the ribavirin group, nor in the placebo group significant statistical differences of the HCV RNA values were found. Significantly lower portal inflammation was noticed in ribavirin group after the treatment. Analysis of laboratory data demonstrated that ribavirin therapy was associated with mild to moderate reversible anemia. Investigator's evaluation of the effect of the therapy on patient's well being showed statistically significant differences in the benefit of the ribavirin group. CONCLUSION:
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Authors | Violeta Stanimirović, Dejan Nikolić, Branko Stanimirović, Aleksandra Nikolić, Spomenka Cucak |
Journal | Vojnosanitetski pregled
(Vojnosanit Pregl)
2002 Sep-Oct
Vol. 59
Issue 5
Pg. 479-84
ISSN: 0042-8450 [Print] Serbia |
PMID | 12451727
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Antiviral Agents
- Ribavirin
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Topics |
- Adult
- Aged
- Antiviral Agents
(therapeutic use)
- Double-Blind Method
- Female
- Hepatitis C, Chronic
(diagnosis, drug therapy)
- Humans
- Male
- Middle Aged
- Ribavirin
(therapeutic use)
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