Abstract | PURPOSE: To evaluate the T1 efficacy of EVP-ABD, a new manganese (Mn)-based contrast agent, for vascular and liver tissue enhancement in comparison with currently approved agents. MATERIALS AND METHODS: Ten Yorkshire pigs ( body weight, 26 -46 kg) were used for the efficacy evaluation, nine for kinetic T1 evaluation (three each agent) and one for post EVP-ABD imaging. With a fast imaging scheme to monitor T1 values of blood and liver, 10 micromol/kg EVP-ABD was injected intravenously and compared with gadopentetate dimeglumine ( Magnevist, GdDTPA) and mangafodipir trisodium ( Teslascan, mangafodipir trisodium) at routine clinical dosages. All were imaged with 3D T1 Gradient Recalled Echo (GRE) sequence (TR/TE/alpha = 3.8/1.6/25 degrees ) prior to and 10 minutes post injection using a 1.5-T whole-body scanner. Additional high-resolution 2D liver images (TR/TE/alpha = 50/4.6/40 degrees ) and arterial phase images of the upper aorta were acquired from the pig for post EVP-ABD imaging. RESULTS:
At 10 micromol/kg, EVP-ABD provided a dramatic decline in blood T1, comparable to 0.1 mmol/kg GdDTPA, followed by a rapid return to blood baseline T1 values. In addition to the blood enhancement phase, EVP-ABD achieved a 70% reduction in liver T1 within 2 minutes postadministration, with an imaging window of at least 2 hours. A substantially improved signal-to-noise ratio (SNR) was observed in both the 2D and 3D liver images postcontrast. CONCLUSION:
EVP-ABD demonstrated peak vascular enhancement similar to GdDTPA and prolonged specific liver enhancement exceeding mangafodipir trisodium. EVP-ABD has favorable T1 enhancing characteristics with the potential to allow for a comprehensive liver evaluation.
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Authors | C S Zuo, P Seoane, T Lanigan, P Harnish, P V Prasad, P Storey, W Li, N M Rofsky |
Journal | Journal of magnetic resonance imaging : JMRI
(J Magn Reson Imaging)
Vol. 16
Issue 6
Pg. 668-75
(Dec 2002)
ISSN: 1053-1807 [Print] United States |
PMID | 12451580
(Publication Type: Comparative Study, Evaluation Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Copyright | Copyright 2002 Wiley-Liss, Inc. |
Chemical References |
- Contrast Media
- EVP-ABD
- Manganese
- Pyridoxal Phosphate
- Edetic Acid
- Gadolinium DTPA
- N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid
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Topics |
- Animals
- Aorta
- Contrast Media
(pharmacokinetics)
- Edetic Acid
(analogs & derivatives, pharmacokinetics)
- Gadolinium DTPA
(pharmacokinetics)
- Liver
(blood supply)
- Magnetic Resonance Imaging
- Manganese
- Pyridoxal Phosphate
(analogs & derivatives, pharmacokinetics)
- Swine
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