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[Multifocal progressive leukoencephalitis in a patient given fludarabine for chronic lymphoid leukemia].

Abstract
A 74-year- man was hospitalized for subacute aphasia and right hemiparesis. He had had chronic lymphoid leukemia for 11 years and had been treated 5 months earlier with 3 courses of fludarabine. Magnetic resonance imaging showed lesions of the temporo-occipital white matter compatible with progressive multifocal leukoencephalitis (PML). The presence of JC virus was demonstrated first by in situ hybridation after a brain biopsy and second with polymerase chain reaction on CSF. The diagnosis of PML was confirmed. The causality of fludarabine treatment is discussed.
AuthorsS Léonard, C Hulin, R Anxionnat, Y Grignon, L Taillandier, H Vespignani
JournalRevue neurologique (Rev Neurol (Paris)) Vol. 158 Issue 11 Pg. 1121-3 (Nov 2002) ISSN: 0035-3787 [Print] France
Vernacular TitleLeucoencéphalopathie multifocale progressive après traitement par fludarabine dans une leucémie lymphoïde chronique.
PMID12451348 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Vidarabine
  • fludarabine
Topics
  • Aged
  • Antineoplastic Agents (adverse effects)
  • Biopsy
  • Brain (pathology)
  • Chronic Disease
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell (drug therapy)
  • Leukoencephalopathy, Progressive Multifocal (cerebrospinal fluid, chemically induced, diagnosis)
  • Male
  • Polymerase Chain Reaction
  • Vidarabine (adverse effects, analogs & derivatives)

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