Abstract |
A 74-year- man was hospitalized for subacute aphasia and right hemiparesis. He had had chronic lymphoid leukemia for 11 years and had been treated 5 months earlier with 3 courses of fludarabine. Magnetic resonance imaging showed lesions of the temporo-occipital white matter compatible with progressive multifocal leukoencephalitis (PML). The presence of JC virus was demonstrated first by in situ hybridation after a brain biopsy and second with polymerase chain reaction on CSF. The diagnosis of PML was confirmed. The causality of fludarabine treatment is discussed.
|
Authors | S Léonard, C Hulin, R Anxionnat, Y Grignon, L Taillandier, H Vespignani |
Journal | Revue neurologique
(Rev Neurol (Paris))
Vol. 158
Issue 11
Pg. 1121-3
(Nov 2002)
ISSN: 0035-3787 [Print] France |
Vernacular Title | Leucoencéphalopathie multifocale progressive après traitement par fludarabine dans une leucémie lymphoïde chronique. |
PMID | 12451348
(Publication Type: Case Reports, English Abstract, Journal Article)
|
Chemical References |
- Antineoplastic Agents
- Vidarabine
- fludarabine
|
Topics |
- Aged
- Antineoplastic Agents
(adverse effects)
- Biopsy
- Brain
(pathology)
- Chronic Disease
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
(drug therapy)
- Leukoencephalopathy, Progressive Multifocal
(cerebrospinal fluid, chemically induced, diagnosis)
- Male
- Polymerase Chain Reaction
- Vidarabine
(adverse effects, analogs & derivatives)
|