Abstract | BACKGROUND: OBJECTIVE: We evaluated the determinants of tHcy in healthy French adults. DESIGN: tHcy was measured by HPLC and fluorometric detection in 1139 women and 931 men aged 35-60 y. Subjects were participants of the Supplementation with Antioxidant Vitamins and Minerals Study, which investigates the effects of antioxidant supplementation on chronic diseases. Red blood cell folate (RBCF), plasma vitamins B-6 and B-12, and cardiovascular disease risk factors were also measured. The habitual diet was assessed in 616 subjects. Cross-sectional analyses were adjusted for age, smoking, energy intake, and concentration or intake of folate and vitamin B-6, where appropriate. RESULTS: The mean (+/-SD) tHcy concentration was 8.74 +/- 2.71 micro mol/L in women and 10.82 +/- 3.49 micro mol/L in men. In women, tHcy was positively related to age (P = 0.001), apolipoprotein B (P < 0.01), serum triacylglycerol (P < 0.01), fasting glucose (P = 0.02), and coffee and alcohol consumption (both P < 0.01) and inversely related to RBCF (P = 0.11) and plasma vitamin B-12 (P = 0.08) and vitamin B-6 (P = 0.01) intakes. In men, tHcy was positively associated with body mass index (P = 0.03), blood pressure (P < 0.02), serum triacylglycerol (P < 0.01), fasting glucose (P = 0.01), and energy intake (P < 0.01) and inversely associated with physical activity (P = 0.04), RCBF (P = 0.02), plasma vitamin B-12 (P = 0.09), and dietary fiber (P < 0.01), folate (P = 0.03), and vitamin B-6 (P = 0.09) intakes. CONCLUSION: To control tHcy, decreasing coffee and alcohol consumption may be important in women, whereas increasing physical activity, dietary fiber, and folate intake may be important in men.
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Authors | Louise I Mennen, Geneviève Potier de Courcy, Jean-Claude Guilland, Véronique Ducros, Sandrine Bertrais, Jean-Pierre Nicolas, Michèle Maurel, Marjorie Zarebska, Alain Favier, Claire Franchisseur, Serge Hercberg, Pilar Galan |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 76
Issue 6
Pg. 1279-89
(Dec 2002)
ISSN: 0002-9165 [Print] United States |
PMID | 12450894
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Apolipoproteins B
- Blood Glucose
- Coffee
- Dietary Fiber
- Minerals
- Triglycerides
- Vitamins
- Homocysteine
- Vitamin B 6
- Folic Acid
- Vitamin B 12
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Topics |
- Adult
- Aging
- Alcohol Drinking
- Antioxidants
(administration & dosage)
- Apolipoproteins B
(blood)
- Blood Glucose
(analysis)
- Body Constitution
- Body Mass Index
- Cardiovascular Diseases
(blood)
- Chromatography, High Pressure Liquid
- Coffee
- Dietary Fiber
(administration & dosage)
- Dietary Supplements
- Energy Intake
- Erythrocytes
(chemistry)
- Exercise
- Fasting
- Female
- Folic Acid
(blood)
- France
- Homocysteine
(blood)
- Humans
- Male
- Middle Aged
- Minerals
(administration & dosage)
- Risk Factors
- Sex Characteristics
- Triglycerides
(blood)
- Vitamin B 12
(blood)
- Vitamin B 6
(blood)
- Vitamins
(administration & dosage)
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