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[Involvement of microbial alkyl hydroxybenzenes in the regulation of autolytic degradation of yeast cells].

Abstract
A comparative study was performed of the processes of autolytic degradation of the cells of Saccharomyces cerevisiae and Schizosaccharomyces pombe under conditions simulating the phase of cell death in microbial cultures: (1) during autolysis induced by oleic acid, which is the chemical analogue of factors d2 (autolysis autoinducer), (2) under the effect of extracellular microbial proteinases (enzymatic lysis), and (3) under concomitant effect of the enzymes of the endogenous autolytic complex and exogenous proteinases (heterolysis). Regulatory mechanisms controlling the rate and profundity of autolysis were elucidated, relying on the stabilization of hydrolytic enzymes and enhancement of their activity in their complexes with a chemical analogue of microbial autoregulatory factors d1, which belong to alkylhydroxybenzenes and fulfil functions of chemical chaperons. The changes in the activity of proteinases and enzymes of the autolytic complex were shown to be dependent on the concentration of the analogue at the moment of complex formation.
AuthorsT A Karpekina, I Iu Stepanenko, E I Krylova, A N Kozlova, I M Gracheva, G I El'-Registan
JournalMikrobiologiia (Mikrobiologiia) 2002 Sep-Oct Vol. 71 Issue 5 Pg. 611-8 ISSN: 0026-3656 [Print] Russia (Federation)
Vernacular TitleUchastie mikgobnykh alkiloksibenzolov v reguliatsii avtoliticheskoĭ destruktsii drozhzhevykh kletok.
PMID12449626 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Alkalies
  • Oleic Acid
  • Phenol
  • Endopeptidases
Topics
  • Alkalies (metabolism)
  • Endopeptidases (pharmacology)
  • Homeostasis
  • Oleic Acid (pharmacology)
  • Phenol (metabolism, pharmacology)
  • Saccharomyces cerevisiae (drug effects, physiology)
  • Schizosaccharomyces (drug effects, physiology)

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