Abstract | BACKGROUND:
Bowen's disease is a common skin cancer. There are many different therapeutic approaches to treatment. Topical 5-Fluorouracil (5-FU) cream has been used for many years and there are many published papers attesting to its effectiveness. However, no papers have presented long-term followup results with biopsy confirmation of cure. OBJECTIVES: The purpose of this article is to present the long-term findings following the use of this cream in the treatment of Bowen's disease. METHODS: Twenty-four patients with 26 biopsy-confirmed lesions of Bowen's disease were treated with topical 5-Fluorouracil cream and were followed for periods of up to 10 years. Posttreatment biopsies were performed in most cases. RESULTS: Two of the 26 lesions treated topically recurred at some point. The rest were apparently cured. CONCLUSION: The results presented in this article confirm that treatment of Bowen's disease with topical 5-Fluorouracil cream is safe and effective treatment.
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Authors | Howard Bargman, Jacqueline Hochman |
Journal | Journal of cutaneous medicine and surgery
(J Cutan Med Surg)
2003 Mar-Apr
Vol. 7
Issue 2
Pg. 101-5
ISSN: 1203-4754 [Print] United States |
PMID | 12447619
(Publication Type: Journal Article)
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Chemical References |
- Antimetabolites, Antineoplastic
- Fluorouracil
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Topics |
- Aged
- Aged, 80 and over
- Antimetabolites, Antineoplastic
(therapeutic use)
- Bowen's Disease
(drug therapy)
- Female
- Fluorouracil
(therapeutic use)
- Humans
- Male
- Middle Aged
- Skin Neoplasms
(drug therapy)
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