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Topical treatment of Bowen's disease with 5-Fluorouracil.

AbstractBACKGROUND:
Bowen's disease is a common skin cancer. There are many different therapeutic approaches to treatment. Topical 5-Fluorouracil (5-FU) cream has been used for many years and there are many published papers attesting to its effectiveness. However, no papers have presented long-term followup results with biopsy confirmation of cure.
OBJECTIVES:
The purpose of this article is to present the long-term findings following the use of this cream in the treatment of Bowen's disease.
METHODS:
Twenty-four patients with 26 biopsy-confirmed lesions of Bowen's disease were treated with topical 5-Fluorouracil cream and were followed for periods of up to 10 years. Posttreatment biopsies were performed in most cases.
RESULTS:
Two of the 26 lesions treated topically recurred at some point. The rest were apparently cured.
CONCLUSION:
The results presented in this article confirm that treatment of Bowen's disease with topical 5-Fluorouracil cream is safe and effective treatment.
AuthorsHoward Bargman, Jacqueline Hochman
JournalJournal of cutaneous medicine and surgery (J Cutan Med Surg) 2003 Mar-Apr Vol. 7 Issue 2 Pg. 101-5 ISSN: 1203-4754 [Print] United States
PMID12447619 (Publication Type: Journal Article)
Chemical References
  • Antimetabolites, Antineoplastic
  • Fluorouracil
Topics
  • Aged
  • Aged, 80 and over
  • Antimetabolites, Antineoplastic (therapeutic use)
  • Bowen's Disease (drug therapy)
  • Female
  • Fluorouracil (therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Skin Neoplasms (drug therapy)

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