Changes in pyridoxal kinase immunoreactivity in the gerbil hippocampus following spontaneous seizure.

Abstract	To identify the roles of pyridoxal kinase (PLK) in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of PLK expression in the gerbil hippocampus was conducted. PLK immunoreactivity in a pre-seizure group of seizure sensitive (SS) gerbils was more strongly detected than that in a seizure resistant (SR) group. The density of PLK immunoreactivity in a 30-min postictal group was significantly lower than that of a pre-seizure group. In a 12 h postictal group, PLK immunodensity recovered to pre-seizure level. The over-expression of PLK in the hippocampus of pre-seizure SS gerbils suggests that PLP play an important role in the modulation of GAD activity and GABA reuptake as mediated by membrane transporter via neurons.
Authors	Tae Cheon Kang, Seung Kook Park, In Koo Hwang, Sung Jin An, Jae Hoon Bahn, Dae Won Kim, Soo Young Choi, Oh Shin Kwon, Nam In Baek, Hyeon Yong Lee, Moo Ho Won
Journal	Brain research (Brain Res) Vol. 957 Issue 2 Pg. 242-50 (Dec 13 2002) ISSN: 0006-8993 [Print] Netherlands
PMID	12445966 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Carrier Proteins GABA Plasma Membrane Transport Proteins Isoenzymes Membrane Proteins Membrane Transport Proteins Organic Anion Transporters gamma-Aminobutyric Acid Pyridoxal Kinase Glutamate Decarboxylase glutamate decarboxylase 1 glutamate decarboxylase 2
Topics	Animals Carrier Proteins (metabolism) Cell Membrane (metabolism) Dentate Gyrus (enzymology, physiopathology) Down-Regulation (physiology) Epilepsy (enzymology, physiopathology) Fluorescent Antibody Technique GABA Plasma Membrane Transport Proteins Gerbillinae Glutamate Decarboxylase (metabolism) Hippocampus (enzymology, physiopathology) Immunohistochemistry Isoenzymes (metabolism) Membrane Proteins (metabolism) Membrane Transport Proteins Neural Inhibition (physiology) Neurons (enzymology) Organic Anion Transporters Pyridoxal Kinase (metabolism) Reaction Time (physiology) gamma-Aminobutyric Acid (metabolism)

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