Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice.

Abstract

Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells significantly enhances the response of these cells to the growth-inhibitory actions of melatonin. Athymic nude mice implanted with MT1-overexpressing MCF-7 cells developed significantly fewer palpable tumors (60% reduction) compared to mice receiving vector-transfected MCF-7 cells (vt-MCF-7). In response to exogenous melatonin, tumor incidence in the mice receiving the MT1-overexpressing MCF-7 cells was decreased by 80% compared to mice receiving vt-MCF-7 cells. Interestingly, daily melatonin administration did not decrease tumor incidence in mice receiving vt-MCF-7 cells, but rather stimulated overall tumor formation.

• Authors: A Collins, L Yuan, T L Kiefer, Q Cheng, L Lai, S M Hill
• Journal: Cancer letters (Cancer Lett) Vol. 189 Issue 1 Pg. 49-57 (Jan 10 2003) ISSN: 0304-3835 [Print] Ireland
• PMID: 12445677 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Receptors, Cell Surface
• Receptors, Cytoplasmic and Nuclear
• Receptors, Melatonin
• Melatonin

Topics

• Animals
• Breast Neoplasms (prevention & control)
• Female
• Humans
• Melatonin (pharmacology)
• Mice
• Mice, Nude
• Neoplasm Transplantation
• Receptors, Cell Surface (genetics, metabolism, physiology)
• Receptors, Cytoplasmic and Nuclear (genetics, metabolism, physiology)
• Receptors, Melatonin
• Transfection
• Transplantation, Heterologous
• Tumor Cells, Cultured