Estrogens in female thyroid cancer: alteration of urinary profiles in pre- and post-operative cases.

Abstract

To evaluate the potential effect of estrogens in premenopausal female thyroid cancer, the concentrations of 14 estrogens were quantitatively determined in the urine of pre- and post-operative patients with thyroid papillary cancer (18 patients case, 26 approximately 54 years) and normal female subjects (20 cases, 31 approximately 52 years). The highly sensitive gas chromatography-mass spectrometry-selected ion-monitoring method was used for estrogens analysis. And an estrogen-oxidative metabolism and 16alpha-hydroxyestrone to 2-hydroxyestrone (16alpha-OH E1/2-OH E1) which is the two primary and competing site of estrogen-oxidation, were determined. Catechol estrogens, including 2-OH E1, were also increased without significant changes of the other estrogen metabolites in pre-operative patients with thyroid papillary cancer compared with normal subjects. The lowest mean value of 16alpha-OH E1/2-OH E1 was remarked in pre-operative patients, and it was significantly different from the ratio of post-operative cases. As a result, it is suggested that the increase of 2-hydroxylation in estrogen metabolism may have a significant association with female thyroid cancer.

• Authors: Seon Hwa Lee, Kyung Mee Kim, Byung Hwa Jung, Woung Youn Chung, Cheong Soo Park, Bong Chul Chung
• Journal: Cancer letters (Cancer Lett) Vol. 189 Issue 1 Pg. 27-32 (Jan 10 2003) ISSN: 0304-3835 [Print] Ireland
• PMID: 12445674 (Publication Type: Journal Article)

Chemical References

• Estrogens
• Hydroxyestrones
• 16-hydroxyestrone

Topics

• Adult
• Estrogens (urine)
• Female
• Humans
• Hydroxyestrones (urine)
• Middle Aged
• Postoperative Period
• Thyroid Neoplasms (surgery, urine)