The isolation of two new chromone derivatives from the New Zealand fungus Tolypocladium extinguens.

Abstract

Two new chromone derivatives, 6-methoxymethyleugenin (1) and 2-hydroxymethyl-6-methoxymethyleugenin (2), and the previously reported 6-hydroxymethyleugenin (3) were isolated from the New Zealand fungus Tolypocladium extinguens. The structures of these compounds were elucidated on the basis of spectroscopic data. 6-Methoxymethyleugenin (1) showed moderate cytotoxicity against P388 leukemia cells.

• Authors: Yunjiang Feng, John W Blunt, Anthony L J Cole, Murray H G Munro
• Journal: Journal of natural products (J Nat Prod) Vol. 65 Issue 11 Pg. 1681-2 (Nov 2002) ISSN: 0163-3864 [Print] United States
• PMID: 12444701 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-hydroxymethyl-6-methoxymethyleugenin
• 6-hydroxymethyleugenin
• 6-methoxymethyleugenin
• Antineoplastic Agents
• Chromones

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Chromones (chemistry, isolation & purification, pharmacology)
• Diptera (chemistry)
• Drug Screening Assays, Antitumor
• Fungi (chemistry)
• Leukemia P388
• Molecular Conformation
• Molecular Structure
• New Zealand
• Nuclear Magnetic Resonance, Biomolecular
• Spectroscopy, Fourier Transform Infrared
• Tumor Cells, Cultured (drug effects)